TEHRAN: Iranians and Israelis woke to smoke and rubble on Sunday after the arch-rivals expanded their attacks overnight, with Israel striking Tehran’s defence ministry, and Iran unleashing a deadly barrage of missiles.Air raid sirens and explosions were heard by AFP journalists in Jerusalem and Tel Aviv early Sunday, as Israel’s military said millions of Israelis were “running for shelter” around the country.Israel’s emergency services said at least eight people, including children, were killed in the overnight strikes, and around 200 were wounded.In Iran’s capital, AFP journalists heard a series of blasts at around 2:30 am.The third day of tit-for-tat attacks comes despite global calls for de-escalation, with Iran scrapping its latest nuclear talks with the United States, saying it could not negotiate while under fire from Israel.After decades of enmity and conflict by proxy, it is the first time the arch-enemies have traded fire with such intensity, triggering fears of a prolonged conflict that could engulf the Middle East.Israel’s operation, which began early Friday, has targeted Iranian nuclear and military sites, killing dozens of people including top army commanders and atomic scientists, according to Tehran.In Bat Yam, outside of Tel Aviv, Israeli first responders wearing helmets and headlamps combed through the rubble of a building as dawn broke.Two women, aged 69 and 80, a girl and a 10-year-old boy were killed, while about 100 others were wounded, according to a spokesperson for Magen David Adom (MDA).In Shfela region, west of Jerusalem, another 37 people were wounded, the MDA spokesperson added.In the north of Israel, in the Western Galilee, rescuers said a strike late Saturday destroyed a three-storey building, killing three women.A woman in her 20s also died after an Iranian missile hit a home in the Haifa region, leaving about a dozen people wounded, MDA said.An MDA spokesman told Israeli broadcaster Channel 12 that around 200 people were wounded in the overnight missile strikes fired by Iran.Iran’s UN ambassador said 78 people were killed and 320 wounded in Friday’s first wave of Israeli strikes. Iranian authorities have not provided an updated toll as of early Sunday.‘Nuclear project’ sites struckIsrael’s military said it had struck Iran’s defence ministry headquarters, “nuclear weapons project” infrastructure sites and other targets, including fuel tankers, just before 2:40 am on Sunday (2340 GMT Saturday).The targeted sites, including the “headquarters of the SPND (Organization of Defensive Innovation and Research) nuclear project”, advanced Iran’s efforts to obtain a nuclear weapon, according to Israel.Iranian news agency Tasnim earlier reported that an Israeli strike had targeted the defence ministry headquarters in Tehran and damaged one of its buildings. The ministry did not comment.Iran’s Revolutionary Guards said Sunday that the country had struck sites used by Israeli warplanes for refuelling, in retaliation for the strikes carried out by Israel.Overnight, Israel stuck two fuel depots in Tehran, the Iranian oil ministry said Sunday.According to the ministry, the oil depots at Shahran northwest of Tehran and another reservoir south of the city were hit.Netanyahu maintained Israel’s operation had the “clear support” of US President Donald Trump.