J Pain Res. 2025 Jun 24;18:3117-3139. doi: 10.2147/JPR.S521788. eCollection 2025.ABSTRACTPeripheral nerve stimulation (PNS) has evolved with various applications and durations of therapy. In recent years, extensive data has been developed on a 60-day treatment using a novel approach. Confusion exists on the use of a trial therapy, a permanent implant, and a 60-day duration treatment. The American Society of Pain and Neuroscience (ASPN) seeks to clarify the literature associated with this neuromodulation approach. A diverse group of experts was nominated to provide opinions and guidance based on evidence-graded assessment and clinical knowledge. This guidance is the first to specifically assess the clinical use of 60-day PNS and best medical practice.PMID:40590046 | PMC:PMC12206896 | DOI:10.2147/JPR.S521788