Inquiry. 2025 Jan-Dec;62:469580251348133. doi: 10.1177/00469580251348133. Epub 2025 Jun 27.ABSTRACTFunctional resistance training (FRT) has been among the most popular fitness trends worldwide for over a decade, driven by its emphasis on movement patterns essential for daily activities and maintaining functional independence. Despite its widespread use, research exploring the impact of FRT on quality of life (QoL) remains sparse and of limited methodological quality, particularly among middle-aged adults (40-60 years old). This review addresses these gaps by synthesizing existing literature on FRT and its effects on muscle strength, movement efficiency, and QoL in this underrepresented demographic. While traditional resistance training builds muscle strength, mass, and endurance, FRT targets functional movement patterns, making it well-suited to sustaining independence during the aging process. By shedding light on the potential of FRT to improve quality of life (QoL) and mobility in middle-aged populations, this review provides actionable insights for healthcare and fitness professionals. Further research is needed to determine long-term outcomes and create evidence-based guidelines for integrating FRT into age-friendly health systems.PMID:40575939 | DOI:10.1177/00469580251348133