Clin Transl Oncol. 2025 Jul 11. doi: 10.1007/s12094-025-03979-x. Online ahead of print.ABSTRACTPURPOSE: Cancer frequently leads to reduced cardiorespiratory fitness (CRF), altered body composition, and increased fatigue, negatively impacting quality of life. This study aimed to evaluate the effects of a multimodal oncological exercise program on CRF, body composition, functional capacity, fatigue, and quality of life in breast cancer survivors.METHODS: Seventy-four breast cancer survivors (stages IA-IIIB) were randomized to either an intervention group (n = 40), participating in a 16-week, twice-weekly multimodal exercise program (in-person or online), or a control group (n = 34). CRF was the primary outcome. Measurements were taken at baseline and post-intervention.RESULTS: The intervention group showed significant improvements in CRF (+22.4%), fat mass (-10%), and lean mass (+5.24%). Functional capacity and physical activity levels also increased. No significant differences were found between in-person and online delivery formats, suggesting the effectiveness of remote interventions.CONCLUSIONS: A 16-week structured, multimodal exercise program significantly improved CRF, body composition, and physical function in breast cancer survivors. Comparable outcomes between in-person and online formats support the feasibility and utility of remote exercise programs in oncology care.PMID:40643869 | DOI:10.1007/s12094-025-03979-x