Sustainable packaging is only the beginning. What a medicine is made from—and how its ingredients are produced—matters just as much. Yet the synthesis of compounds for pharmaceutical research can still depend on fossil feedstocks, high temperatures, strong oxidants and metals that raise costs and complicate purification. Two recently published studies from Colmenares' group at IPC PAS demonstrate that cleaner chemistry can begin at the level of a single chemical bond. The studies are published in the journal Ultrasonics Sonochemistry and Chemistry—A European Journal.