Turning their attention back to Champions League action on Wednesday night, Real Madrid will welcome RB Leipzig to the Spanish capital.With another stacked European schedule from across the continent, there are plenty of eye-catching Champions League betting promotions available.Verdict: Real Madrid win & Both teams to score Best Odds: 7/5Bookmaker: BetUSReal MadridStarting with the hosts, while Real Madrid might have entered September’s extended international break with a 2-1 loss away at arch-rivals Atletico, it appears that was just a minor blip for Jose Mourinho’s superstar squad. Mounting what was an iconic Champions League comeback on foreign soil last week as they eventually left Rome with a remarkable 4-3 victory, Los Blancos have won six of their previous seven appearances across all competitions. Laying down another European marker last month as they opened their Champions League adventure with a 2-1 win at home against Italian giants Inter Milan, Real Madrid have their sights fixed on mounting a genuine title charge this year. Extending on their recent flurry over the weekend as they clinched a thumping 4-1 victory against Sevilla, Mourinho’s side will now be hoping to find some much-welcomed defensive grit.Real Madrid Team NewsWhile Brazilian superstar Vinicius Junior might be serving a controversial domestic suspension, the 26-year-old is free to feature here. However, all dealing with respective injury issues, Real Madrid will be unable to call upon the trio of Rodrygo, Ferland Mendy and Spanish defender Raul Asencio on Wednesday night.Bagging a La Liga brace against Sevilla over the weekend and also notching consecutive Champions League strikes, French skipper Kylian Mbappe will spearhead Madrid’s attack. Likewise, making a real impact since complete a blockbuster summer switch from Leipzig, new recruit Yan Diomande will join Mbappe in the final third.RB LeipzigAs for the visitors, completely blown away over the weekend as they slumped to a nightmare 6-1 drumming against reigning German champions Bayern Munich, RB Leipzig will be bracing themselves for another monumental challenge on Wednesday night. Getting their Champions League adventure underway with a worrying 4-1 loss at the hands of Italian outfit Como, Martin Demichelis’ inconsistent squad have continued to show some rather glaring issues away from the Red Bull Arena. Heading into September’s extended international break with a routine 2-0 defeat against domestic rivals Bayer Leverkusen, RB Leipzig have now lost all of their previous four straight away fixtures across all competitions by an aggregate score of 15-2. It should also be highlighted, Wednesday’s guests have failed to muster a single clean sheet away at top-flight opposition since the end of January.RB Leipzig Team NewsAll still dealing with respective injury issues, RB Leipzig will travel to Madrid on Wednesday night without the trio of Assan Ouedraogo, Christoph Baumgartner and former Chelsea misfit Marc Guiu. Completing another season-long loan switch from Brighton over the summer, Brajan Gruda will feature here.Making a return to the Red Bull Arena last month and notching for goals in his first six Bundesliga appearances, Christopher Nkunku will spearhead Leipzig’s attack. French international Castello Lukeba will partner Willi Urban at the heart of Demichelis’ defence.Real Madrid vs RB Leipzig Key Factors to ConsiderWhen Real Madrid and RB Leipzig last met for a Champions League showdown back in March 2024, Los Blancos claimed a 2-1 aggregate victory in the Round of 16.Real Madrid have won six of their previous seven appearances across all competitions.RB Leipzig have lost each of their previous four straight matchups away from the Red Bull Arena across all competitions by an aggregate score of 15-2.French skipper Kylian Mbappe has registered 10 goals for club and country so far this season.Leipzig have failed to register a single clean sheet away at top-flight opposition since the end of January.ConclusionWhile Real Madrid might have a major battle on their hands in the race to recapture their La Liga crown, Los Blancos should find the mood in their camp at a real high. Mounting a remarkable Champions League comeback away at Roma last week and opening their European adventure with back-to-back victories, Mourinho’s side will be looking to make another statement here. Winning six of their previous seven appearances across all competitions, Madrid will meet Leipzig squad who have continued to show a string of glaring issues on the road.Verdict: Real Madrid win & Both teams to scoreBest Odds: 7/5Bookmaker: BetUSThe post Prediction: Real Madrid vs RB Leipzig appeared first on SoccerNews.