A major European survey marks a significant milestone in the effort to control antimicrobial resistance (AMR), providing the most comprehensive genomic picture to date of carbapenem- and/or colistin-resistant Enterobacterales (CCRE) across hospitals in Europe. Carbapenem-resistant Enterobacterales are critical priority pathogens posing a high risk for public health and patient safety, as they cause difficult-to-treat infections with limited available treatment options and an insufficient development pipeline for new antibiotics.