by Jean FanSince the founding of PLOS Computational Biology 20 years ago, genomics research has advanced at a remarkable pace. In this 20th anniversary commentary, as an Editor for the Journal Section of Genomics, Epigenomics, & Proteomics, I take a data-driven dive into genomics research at PLoS Computational Biology by analyzing all submitted research papers in this section since 2017. This time window reflects the limits of the Editorial Manager records we were able to assemble, but it also coincides approximately with my own independent journey in this field. While this time window does not capture the journal’s full 20-year history, I hope this analysis will offer a data-driven reflection on how genomics research within the journal has evolved and provide a putative trajectory on how the field will surely continue to grow into the future.