A new era begins for the Buffalo Bills as they play their first regular-season game at their $2.2 billion new Highmark Stadium on Thursday night against the Detroit Lions.With both teams known for their high-powered offences, a cracking game is in prospect in this AFC v NFC clash, especially after both teams won their opening games.Both their Week 1 contests ended up being close, though, as the Bills beat the Houston Texans 36-31 after twice losing the lead in the fourth quarter, while the Lions beat the New Orleans Saints 31-30 after their opponents failed with a two-point conversion attempt that would have won the game in overtime.GET UP TO £30 IN FREE BETS ON THE NFL WITH TALKSPORT BET* Buffalo Bills vs Detroit Lions TipsOver 54.5 points @ 20/23Josh Allen over 254.5 passing yards @ 17/20Dalton Kincaid over 50.5 receiving yards @ 20/23Fans should be treated to a thrilling game in stadium debutThe Bills and Lions finished joint-fourth in the 2025 NFL regular season for points scored and they should combine for an entertaining contest to launch the new Highmark Stadium.The Bills were no strangers to end-to-end shootouts at their old stadium of the same name, as their first home game last season was a 41-40 win over the Baltimore Ravens and later results there included a 44-32 win over the Tampa Bay Buccaneers and a 39-34 success against the Cincinnati Bengals.Both teams began the season with their offences in fine form but questions to be answered by their defences, pointing to another high-scoring encounter.The Bills clocked up 36 points despite facing one of the league’s top defences from the Texans, but they also conceded 31 and Houston completed plenty of long passes down the field.The Lions almost threw away a 21-point lead against the Saints, but they put 31 points on the board in their opener while giving up four touchdowns in the second half.The total points line of 54.5 is the highest of the week, but that’s for a good reason and going over looks the best move.Allen can relish Thursday night spotlightGunslinging quarterback Josh Allen is the unquestioned leader of the Buffalo offence, ably supported by running back James Cook, and he began the season with a strong showing against a tough Houston defence.Allen recorded 334 passing yards and, having averaged 278 in his two playoff appearances last season, a passing yards line of 254.5 for this game looks well within reach.The Lions defence gave up far more than that to an inferior quarterback last week as Saints QB Tyler Shough put up 410 passing yards.While Allen is unlikely to approach the 56 pass attempts Shough made, he knows the Lions’ defence can be vulnerable if he takes long shots downfield.Kincaid can play a key roleTight end Dalton Kincaid made a fantastic start to the season when he led the Bills in receiving yards against Houston and the former first-round draft pick can show up well against the Lions too.Kincaid gained 130 yards on just five receptions, with a longest play of 40 yards, and may not need to see as many targets on Thursday night to exceed his line of 50.5.He clearly has the trust of QB Allen and the Saints’ tight ends had success against the Lions defence on Sunday, with Juwan Johnson catching three passes for 54 yards and a touchdown, while Noah Fant added 33 yards from four receptions and also scored.GET UP TO £30 IN FREE BETS ON THE NFL WITH TALKSPORT BET*All odds correct at time of writingtalkSPORT BET CanadatalkSPORT BET is live in Canada!Following on from our success in the UK & Ireland, we have launched in Canada.All residents outside of Ontario can now sign up and bet with talkSPORT BET. Bet $10 at odds of +100 and get triple your returns up to $300! – CLAIM HERET&Cs: 19+ New customers only. Opt in, bet max $10 on any sport single in 7 days, at odds +100 or greater. If it wins we Triple (x3) your returns, up to $300 in Free Bets, expires in 7 days. T&Cs apply, click for T&Cs. Responsiblegambling.org | Please gamble responsiblyRemember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamcare – www.gamcare.org.ukGambleAware – www.gambleaware.orgFind our detailed guide on responsible gambling practices here.For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.