Abstract Background Oral cholera vaccines (OCVs) are a key component of cholera control recommended in cholera-endemic areas. Yet evidence of their population-level impact is limited, especially in Africa where most cholera deaths occur. Here, we estimate the impact of mass administration of OCVs in the cholera-endemic city of Uvira, Democratic Republic of the Congo. Methods We conducted enhanced cholera surveillance at the two official cholera treatment facilities in Uvira between Jan 2017 and Dec 2023, centered around a mass vaccination campaign that achieved 66% coverage with at least one dose of Euvichol Plus vaccine in 2020. We combined systematic rapid diagnostic case testing with repeated, representative population surveys capturing healthcare-seeking behavior, vaccination, population mobility, and antibody profiles to estimate seroincidence. We developed a Bayesian framework that integrates these data into an ensemble of mechanistic cholera transmission models that account for time-varying transmissibility, realistic immunity dynamics and loss of vaccination coverage to population turnover. OCV impact was assessed through ensemble counterfactual modeling of alternative vaccination scenarios. Findings We estimate that the 2020 mass vaccination averted 56% (95% Credible Interval: 34-81) of infections and deaths over the subsequent three years. This corresponds to 2,350 (median, 95% CrI: 890-8,960) averted facility-attended cases, and 44 (median, 95% CrI: 16-150) averted facility and community deaths. Vaccination of the entire eligible population of Uvira would have averted 64% (median, 95% CrI: 43-87) of cases and deaths, with a negative but limited influence of vaccine coverage loss because of population turnover (71% median, 95% CrI: 52-90 at half the population turnover). Interpretation Although mass vaccination averted a significant fraction of cholera cases that would have otherwise occurred in this endemic setting, imperfect coverage, population turnover, and high transmission rates contributed in offsetting the larger potential benefits of OCV. Successful cholera control in Uvira hinges on multisectorial approaches including provision of safe water and sanitation. Setting and communicating realistic expectations for mass vaccination programs in highly endemic areas is critical for maintaining confidence in the current generation of OCVs. Funding Gavi (M&E 9166 09 20 A16) and the Wellcome Trust (221688/Z/20/Z).