A blocked nose can make it difficult to sleep and taste food, and it can get really annoying after a while. Nasal decongestant sprays like oxymetazoline can provide relief, but continued use can worsen nasal obstruction by causing irritation and inflammation in the nasal passages. A recent clinical trial was on a mission to find a combination of drugs that can provide lasting relief from chronic nasal blockage without triggering rebound congestion, a type of nasal obstruction that happens when you overuse nasal decongestant sprays.