The Independent reports that Marco Rubio "is on resignation watch from both sides of the Atlantic in the expectation he will quit to lauch a bid to be the next US President".The report cites "senior party sources in the US and senior figures in the UK government" and notes that he was plotting his exit even before the disasterous midterms. Rival JD Vance already distanced himself from Trump by tring to take an anti-war stance and blaming the Iran war for the Republicans loss. It may be tough for him and Rubio to cast themselves as opponents to war after defending it in the first 9 months of fighting.The Independent said up to five members of Trump's cabinet are considering runs for President. As for Rubio, a source said he needs “distance himself from the Iran war and pin that one on Trump.”I had thought that Rubio would stick around as Secretary of State for a longer period because Cuba has been his longstanding issue and the US appers to be plotting regime change their. Rubio's family immigrated from Cuba prior to Fidel Castro's revolution.In betting markets, the odds for Ron DeSantis have improved dramatically this week as he launches critcisms of the administration as an outsider.This is the nature of politics and now that the Iran war is seen as a failure, none of them will want to take responsibility for it. Meanwhile, none of them resigned in February when the war started, so Vance and Rubio will be vulnerable to attacks from other candidates who say they were never the "America First" politicians they said they were.At the same time, if any of them distance themselves too far from Trump, he will turn thin-skinned and sabotage their candidacies. That set-up may make it easier for outsiders to take leadership of the party.However given the results of the primaries, the real battle to get a Republican president in the next election may come down to policymaking in the next two years. If tariffs, inflation and the Iran war are still going on in 2028, it's tough to imagine any of them having a real chance, given the results on Tuesday. This article was written by Adam Button at investinglive.com.