Added "Aptamer" to the "See also" section← Previous revisionRevision as of 23:24, 3 November 2026 Line 80: Line 80: XNA may be employed as molecular clamps in [[quantitative real-time polymerase chain reaction]]s (qPCR) by hybridizing with target DNA sequences.{{cite journal | vauthors = Sun Q, Pastor L, Du J, Powell MJ, Zhang A, Bodmer W, Wu J, Zheng S, Sha MY | display-authors = 6 | title = A novel xenonucleic acid-mediated molecular clamping technology for early colorectal cancer screening | journal = PLOS ONE | volume = 16 | issue = 10 | article-number = e0244332 | date = 2021-10-05 | pmid = 34610014 | pmc = 8491914 | doi = 10.1371/journal.pone.0244332 | bibcode = 2021PLoSO..1644332S | doi-access = free }} In a study published in [[PLOS One|PLOS ONE]], an XNA-mediated molecular clamping assay detected mutant cell-free DNA (cfDNA) from precancerous [[colorectal cancer]] (CRC) lesions and colorectal cancer. XNAs may additionally act as highly specific molecular probes for detection of nucleic acid target sequence.{{cite journal | vauthors = D'Agata R, Giuffrida MC, Spoto G | title = Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis | journal = Molecules | volume = 22 | issue = 11 | page = 1951 | date = November 2017 | pmid = 29137122 | doi = 10.3390/molecules22111951 | pmc = 6150339 | doi-access = free }} XNA may be employed as molecular clamps in [[quantitative real-time polymerase chain reaction]]s (qPCR) by hybridizing with target DNA sequences.{{cite journal | vauthors = Sun Q, Pastor L, Du J, Powell MJ, Zhang A, Bodmer W, Wu J, Zheng S, Sha MY | display-authors = 6 | title = A novel xenonucleic acid-mediated molecular clamping technology for early colorectal cancer screening | journal = PLOS ONE | volume = 16 | issue = 10 | article-number = e0244332 | date = 2021-10-05 | pmid = 34610014 | pmc = 8491914 | doi = 10.1371/journal.pone.0244332 | bibcode = 2021PLoSO..1644332S | doi-access = free }} In a study published in [[PLOS One|PLOS ONE]], an XNA-mediated molecular clamping assay detected mutant cell-free DNA (cfDNA) from precancerous [[colorectal cancer]] (CRC) lesions and colorectal cancer. XNAs may additionally act as highly specific molecular probes for detection of nucleic acid target sequence.{{cite journal | vauthors = D'Agata R, Giuffrida MC, Spoto G | title = Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis | journal = Molecules | volume = 22 | issue = 11 | page = 1951 | date = November 2017 | pmid = 29137122 | doi = 10.3390/molecules22111951 | pmc = 6150339 | doi-access = free }} == See also == * [[Aptamer]] == References == == References ==