Wembley stadium sets the stage for this Nations League blockbuster between England and Spain on Saturday night.talkSPORT have teamed up with Betfred to bring readers a special Bet Builder for this heavyweight clash, which can be added straight into your bet slip here, and will include the bookie’s new Sub Switch feature which keeps your bet alive even when your player has been substituted.England vs Spain Bet BuilderAdd our 22/1 bet to your betslip HEREKane and Yamal to scoreAnderson 2+ foulsUnder 8.5 cornersThe last time these two sides met was in Berlin in the Euro 2024 final. Spain snatched the game late to win 2-1, and since then have consolidated themselves as the best nation in the world by claiming their first World Cup since 2010.England are licking their wounds from their semi-final exit to Argentina, but boss Thomas Tuchel looks rejuvenated and excited about the challenge the Nations League presents.Harry Kane and Lamine Yamal will be wrestling for supremacy to be Saturday’s star man. Kane has scored seven goals in his last nine England appearances and is in prolific form in the Bundesliga too. Yamal came into the World Cup fresh from injury and may see the Nations League as his platform to announce himself on the international stage.Elliot Anderson has had a sharp rise to prominence in an England shirt, and will face up against World Cup winners Fabian Ruiz, Pedri and Rodri. The Man City midfielder has impressed but this could be his toughest task in a Three Lions shirt.A mouthwatering clash to begin their Nations League campaigns, with some of the worlds best on show and this Betfred bet builder appears top value.How to watch England vs SpainLocation: Wembley Stadium, London, UKDate and time: Saturday 26th September 2026, 7:45pmHow to watch: ITV1, ITVx, STV, STV PlayerAll odds correct at the time of writing.BETFRED – Bet £10 and get £50 in free bets – CLAIM HERE*Commercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. gambleaware.orgRemember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamCare – www.gamcare.org.ukGamble Aware – www.begambleaware.orgFor help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.*New customers only. Register, deposit with Debit Card, and place first bet £10+ at Evens (2.0)+ on Sports within 7 days to get £30 in Sports Free Bets & £20 in Bet Builder Free Bets within 24 hours of settlement. 7-day expiry. Eligibility & payment exclusions apply. Full T&Cs apply.