England face world champions Spain at Wembley on Saturday in one of the standout fixtures of the opening UEFA Nations League round.The match, scheduled for 26 September, kicks off at 20:45 and will see the two teams renew their rivalry after meeting in the 2024 European Championship final.England face a major testThomas Tuchel will be hoping to use the Nations League as the starting point for another major tournament campaign, but England face one of the most difficult opponents available.The Three Lions reached their best World Cup finish since 1966 during the summer, although their performances and tactical approach attracted criticism. Their defeat to Argentina in the semi-finals was their only loss of the tournament, but questions remained over the team’s game management and selection decisions.England have also been inconsistent at Wembley in recent matches, winning two of their last four games and suffering a defeat against Japan.Their preparations have been affected by several withdrawals. Declan Rice, Cole Palmer, Marcus Rashford, Kobbie Mainoo and Tino Livramento have all left the squad because of injuries or workload concerns.Rice and Mainoo’s absences will be particularly significant in midfield, with James Garner expected to partner Elliott Anderson.Spain arrive in strong formSpain has enjoyed an excellent period in international football.La Roja won the European Championship against England before going on to lift the World Cup two years later. They have also gone 18 matches without defeat, with their last loss coming against Portugal in the Nations League.Spain’s squad remains full of technical quality and experience and they appear to have fewer concerns heading into the match. Their control in possession and ability to create chances from wide areas could cause problems for an England side that has gone five matches without keeping a clean sheet.The visitors will be looking to continue their impressive run and make an early statement in the Nations League.England v Spain oddsThe market suggests a closely contested match, with Spain narrowly priced as the favourites despite playing away from home.The fixture is also covered by Meridianbet’s Early Payout offer. If your selected team takes a two-goal lead, your bet may be settled as a winner immediately, subject to the applicable terms and conditions.Odds are subject to change.PredictionEngland’s home advantage should help them remain competitive, but Spain’s stronger squad depth and recent form could make the difference.With key players missing for the hosts and Spain arriving on an 18-match unbeaten run, La Roja may have enough quality to claim the points at Wembley.Prediction: England 1-2 SpainEligible new customers can also claim Meridianbet’s €50 No Deposit Bonus, subject to the applicable terms and conditions.Play responsibly•