TLDR:Mastercard now supports stablecoin settlement using USDC, PYUSD, RLUSD, and four other regulated assets.Settlement runs 24/7, covering intraday windows, weekends, and public holidays across Mastercard’s network.Eight blockchain networks are supported, including Ethereum, Solana, Base, Polygon, and XRPL.Cross River, Lead Bank, ARQ, CBW Bank, and Nuvei are among the first partners going live.Mastercard is opening its settlement infrastructure to regulated stablecoins. The payments giant announced plans to support on-chain card settlement using assets including USDC, PYUSD, and RLUSD. The move introduces intraday, weekend, and holiday settlement options across its global network. It marks one of the most significant stablecoin integrations in mainstream payments to date.Mastercard Enables On-Chain Settlement Using USDC, PYUSD, and RLUSDThe expansion covers a range of regulated stablecoins. Circle’s USDC is already supporting early on-chain settlement flows in select markets. Paxos-issued stablecoins, including PYUSD, USDG, and USDP, are also included. Ripple’s RLUSD and SoFi’s SoFiUSD round out the initial lineup.Settlement will operate across multiple blockchain networks. Supported chains include Arbitrum, Base, Canton, Ethereum, Polygon, Solana, Tempo, and XRPL. Partners can access both traditional and digital asset-based settlement through the same Mastercard infrastructure. Existing protections, including security standards and fraud safeguards, remain in place.The move gives issuers and acquirers more control over liquidity timing. Traditional settlement windows often leave gaps over weekends and public holidays. Mastercard’s expanded options address that directly. The enhancement targets use cases where timing and transparency are critical.Raj Dhamodharan, Mastercard’s executive vice president for Blockchain and Digital Assets, noted that the next phase of stablecoin adoption centers on real-world utility. He pointed specifically to settlement as an area where timing and liquidity matter most. Mastercard framed the launch as expanding how partners operate in an always-on digital economy.Cross River, Lead Bank, and Nuvei Among First to Go LiveSeveral financial firms are expected to be among the first to support the new settlement option. ARQ, formerly known as DolarApp, CBW Bank, Cross River, Lead Bank, and Nuvei are named in Mastercard’s announcement. The initial rollout covers the United States and Latin America. Further expansion is planned through 2026.Cross River’s head of on-chain finance, Luca Cosentino, said demand for faster and more transparent settlement has been accelerating. The firm views stablecoins as a key tool for meeting that demand. Lead Bank CEO Jackie Reses described the development as foundational for a 24/7 financial system. Nuvei CEO Phil Fayer linked the collaboration to a broader strategy of integrating stablecoin capabilities into payments infrastructure.Ripple’s Jack McDonald called the announcement a landmark validation of blockchain technology for critical payment infrastructure. Circle’s chief commercial officer, Kash Razzaghi, highlighted USDC’s role in supporting early on-chain settlement flows. Paxos chief revenue officer Peter Jonas described the development as a trusted path to on-chain settlement that works alongside existing systems.Mastercard said the rollout will continue globally, subject to regulation. Additional regions, partners, and stablecoins are expected to be added over time.The post Mastercard Goes 24/7 With USDC, RLUSD, and PYUSD Settlement Move appeared first on Blockonomi.