Mrs. Puff In a Padded Room is an exploitable reaction image meme format based on a scene from the 2002 SpongeBob SquarePants episode "Doing Time" where Mrs. Puff is shown sitting in the middle of a yellow padded room in a straitjacket, the walls of which turn into SpongeBob's face.A screenshot of Mrs. Puff in the padded room first became the subject of memes in June 2020 on X / Twitter. It became an increasingly popular meme throughout the 2020s. Some of the most popular memes are reaction images where the walls have been edited to show a person's face. These memes use Mrs. Puff to represent someone obsessed over the subject on the walls.Early examples of the meme crossover with the "Being Too Honest With Your Therapist" memes. The meme comes from the same episode as the "SpongeBob Boiling In a Pot" meme format.Read More