Liverpool kick-off their Premier League campaign with a trip to St James’ Park, as Alexander Isak returns to Newcastle for the first time.Sunday marks the dawn of a new era for both clubs, with Andoni Iraola and Matthias Jaissle taking charge of their sides for the first time in the top-flight. St James’ Park will see a new manager in the dugout for the first time since 2021GettyThe Geordies will undoubtedly make their feelings known towards Liverpool frontman Isak, who missed both meeting between the two teams last season following his £125million switch.The Sweden international netted just three league goals last term for the Reds and will be eager to reignite his career at his former home.Former Bournemouth boss Iraola has overseen a major rebuilding project at Liverpool following the departures of several senior figures earlier this summer, including Mohamed Salah, Andy Robertson, and Ibrahima Konate.Meanwhile, the Magpies have sold three of their biggest superstars in Anthony Gordon, Bruno Guimaraes, and Sandro Tonali for an accumulated profit of £240m.However, the club hierarchy have reinvested those funds into six new recruits and have focused heavily on youth.Heading into the fixture, history favours the visitors with Liverpool unbeaten in their last 19 Premier League clashes against the Toon, winning 14 and drawing five.Additionally, Iraola did not lose any of his six Premier League encounters with Newcastle during his tenure in charge of Bournemouth.Where to watch Newcastle v LiverpoolThis fixture will be played on Sunday, August 23 and is scheduled to kick-off at 4:30pm.The match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League following the conclusion of Manchester City v AFC Bournemouth.Ngumoha may become the Premier League’s shining starlet after there was more calls to Arne Slot last season to give the forward more game timeGettytalkSPORT will have updates from the match on GameDay Live with Sam Matterface, Micky Gray and Perry Groves.Listen talkSPORT through the website or find us on DAB digital radio through your smart speaker and on 1089 or 1053 AM.Download and listen to all our live commentaries via the talkSPORT app.For the latest odds and bet boosts for every big event, visit talkSPORT BET.Subscribe to the talkSPORT YouTube channel for news, views and analysis plus our regular goals show and for more, follow us on talkSPORT Facebook and talkSPORT on X.talkSPORT.com will also have all the action in our dedicated Premier League blog.Wirtz has shown promising signs in pre-season for LiverpoolAFPNewcastle v Liverpool: Team newsIsak will be acting as the lone striker as Hugo Ekitike continues his recovery after rupturing his achilles.Operating behind him will almost certainly be Florian Wirtz, who enjoyed a stellar pre-season campaign.On the right wing, youngster Rio Ngumoha is expected to feature, competing for a spot alongside new recruit Víctor Munoz.On the left, Cody Gakpo is expected to start, despite being linked with a move away from the club to Tottenham this summer.The summer signing Jeremy Jacquet is a doubt in defence for the opener after not playing since February due to injury, though the Frenchman scored on debut in pre-season against Como.That means Ronald Araujo could come straight into the starting XI, having just signed on loan from Barcelona, with both Joe Gomez and Giovanni Leoni still sidelined.Meanwhile, Newcastle midfielder Joelinton is out for several weeks with an undisclosed issue, while defenders Tino Livramento and Fabian Schar are both doubtful for their Premier League opening fixture.Following high-profile departures during the transfer window, Jaissle remains stripped of several key figures from Eddie Howe‘s successful tenure.Additionally, while Lewis Miley featured in a recent friendly against Bayer Leverkusen, the midfielder is not expected to be match-ready to start against the Reds.