Tottenham Hotspur still have several fitness and injury worries to contend with ahead of their Premier League opener against Brentford.Tottenham Hotspur are set to kick off their Premier League campaign on Saturday evening against Brentford at the Gtech Stadium.The Lilywhites, who have a solid opening-day record, having won six of their last ten matchweek one games, will be hoping to make it seven in eleven.However, a victory will not come easy, with Brentford equally as strong on the opening matchweek, having lost just once in their last five league openers.Credit: @reclusemedia / InstagramTottenham fitness and injury update ahead of Brentford openerWith the clash against Brentford now only a few days away, Roberto De Zerbi and his staff will be hoping to have a fully fit squad at their disposal.Pre-season turned out to be mostly successful on the fitness front for Spurs, with no player sustaining any long-term injuries.However, a few players remain doubts for Saturday’s encounter. The likes of Destiny Udogie and Micky van de Ven could miss out, having not played a single minute of football during Spurs’ pre-season camp.The pair are not nursing any injuries, with De Zerbi leaving them out as a precaution. On the injury front, though, long-term absentees Mohammed Kudus, Dejan Kulusevski, Wilson Odobert and Xavi Simons are set to miss out.Kudus and Kulusevski returned to outdoor training earlier this month, but Saturday’s clash could come too early for the midfielders.Injured playerInjuryPotential ReturnWilson OdobertKneeNovember 2026Dejan KulusevskiKneeSeptember 2026Mohammed KudusQuadAugust 2026Xavi SimonsKnee2027Dominic SolankeFitnessSoonMicky Van de VenFitnessSoonDestiny UdogieFitnessSoonSpurs’ Dominic Solanke fitness update ahead of Brentford clashAs for Dominic Solanke, it remains touch-and-go. The Englishman did not feature in either of Tottenham’s clashes against Hoffenheim.However, Solanke was spotted engaging in some training drills on Sunday when Spurs took on the German outfit in a behind-closed-doors match at Hotspur Way.He could be passed fit to feature against the Bees this weekend, but it is very unlikely he starts from the off as he continues to manage an ankle knock.James Maddison, who missed out for most of pre-season and only featured on Sunday against Hoffenheim, could also make the matchday squad this weekend.READ MORE: What De Zerbi told Cody Gakpo to leave him ‘hugely impressed’ with Tottenham planThe post Tottenham injury update: Seven Spurs players could miss the trip to Brentford appeared first on Spurs Web.