Sean Brady has pulled out of his Las Vegas main event against Gabriel Bonfim next weekend due to injury.Brady, who handed Leon Edwards his first career stoppage defeat in London last year, was hoping to make it five wins from his last six at UFC Vegas 124 on November 7.Brady has fought in the UFC 11 times since making his promotional debut in 2019GettyThe American bounced back from a first-round knockout loss against Michael Morales in November 2025 by defeating Joaquin Buckley over three rounds at UFC 328 in May.His fight against fellow top-ranked welterweight Bonfim was scheduled to headline the card at Meta Apex, where Briton Davey Grant makes his return.However, a report from Brazilian MMA journalist Laerte Viana has revealed that the American is out of the contest with an injury.The UFC is now on the hunt for a new opponent for Bonfim, who has climbed the welterweight rankings this year with impressive wins over Randy Brown and former champion Belal Muhammad.View Tweet: https://x.com/hashtag/UFCVegas111?src=hash&ref_src=twsrc%5EtfwIn fact, Bonfim has five UFC victories in a row and two Performance of the Night bonuses in the last 18 months.He has suffered just one defeat in Dana White‘s promotion, having emerged through the Contender Series in 2022.It’s far from ideal for Bonfim, who may now face a completely different style of opponent than heavy wrestler Brady.He may also be removed from the card completely if the UFC fails to find a new dance partner in time.But Bonfim will be confident he can continue to surge towards a welterweight title shot no matter who he fights next in the UFC.Ranked just one place below Brady at No. 6, Bonfim is arguably one or two more fights away from his first championship bout.Bonfim is on a five-fight winning streak in the UFCGettyFuture of the UFC’s welterweight divisionIslam Makhachev is the current champion at 170lbs.After defeating Jack Della Maddalena to win the belt last November, the former lightweight king made his first welterweight title defence against Ian Machado Garry at UFC 330 in August.The Russian was then all but confirmed to put the belt on the line against No. 1 contender Carlos Prates at UFC 336 next year.However, Makhachev informed the UFC last week he would not be available for the Toronto card in January.This prompted the promotion to put an interim belt on the line with Prates still involved.Prates instead faces Morales for the interim welterweight title at UFC 336.talkSPORT's UFC pound-for-pound rankingstalkSPORT.com has collectively voted on the best fighters to form a regularly updated UFC pound-for-pound (P4P) rankings system for the rest of 2026 and beyond.Our P4P list will be updated regularly based on performances in the Octagon — with wins, records, title wins and defences, calibre of opponents, methods of victory and much more all determining who makes it.UFC champions Islam Makhachev, Joshua Van and Sean Strickland feature – but big stars such as Alex Pereira and Tom Aspinall miss out.The winner of that is almost certain, barring any injuries, to fight Makhachev for undisputed status next.The UFC has not yet announced whether Bonfim will remain on the card.