An updated clinical guideline from the American Society for Radiation Oncology (ASTRO) provides evidence-based recommendations on the use of hypofractionated radiation therapy for patients with localized prostate cancer. The guideline replaces ASTRO's 2018 recommendations and reflects a matured evidence base showing that shorter-course radiation therapy can maintain cancer control while reducing overall treatment burden for patients receiving definitive external beam radiation therapy (EBRT). The guideline was published in Practical Radiation Oncology.