← Previous revisionRevision as of 03:18, 3 November 2026 Line 20: Line 20: }} }} '''Isotonitazepyne''' ('''''N''-pyrrolidino-[[isotonitazene]], NPI''') is a [[benzimidazole]] derivative with potent [[opioid]] effects, which has been sold as a [[designer drug]] over the internet. Its ''in vitro'' potency is approximately 1000 times that of morphine.{{cite journal | vauthors = De Vrieze LM, Walton SE, Pottie E, Papsun D, Logan BK, Krotulski AJ, Stove CP, Vandeputte MM | title = In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids | journal = Archives of Toxicology | volume = 98 | issue = 9 | pages = 2999–3018 | date = September 2024 | pmid = 38877156 | pmc = 11324687 | doi = 10.1007/s00204-024-03774-7 | bibcode = 2024ArTox..98.2999D }} One sample of counterfeit oxycodone pills were found to contain between 3.3 and 3.5 mg of '''NPI''' per pill and no oxycodone. '''Isotonitazepyne''' ('''''N''-pyrrolidino-[[isotonitazene]], NPI''') is a [[benzimidazole]] derivative with potent [[opioid]] effects, which has been sold as a [[designer drug]] over the internet. Its ''in vitro'' potency is approximately 1000 times that of morphine.{{cite journal | vauthors = De Vrieze LM, Walton SE, Pottie E, Papsun D, Logan BK, Krotulski AJ, Stove CP, Vandeputte MM | title = In vitro structure-activity relationships and forensic case series of emerging 2-benzylbenzimidazole 'nitazene' opioids | journal = Archives of Toxicology | volume = 98 | issue = 9 | pages = 2999–3018 | date = September 2024 | pmid = 38877156 | pmc = 11324687 | doi = 10.1007/s00204-024-03774-7 | bibcode = 2024ArTox..98.2999D }}Glatfelter GC, Maitland AD, Gonzalez NR, Walther D, Chen L, Shi L, Baumann MH. Preclinical pharmacology of N-pyrrolidino "nitazene" opioids appearing in nonmedical drug markets. ''J Pharmacol Exp Ther''. 2026 Aug;393(8):104977. {{doi|10.1016/j.jpet.2026.104977}} {{pmid|42509124}} One sample of counterfeit oxycodone pills were found to contain between 3.3 and 3.5 mg of '''NPI''' per pill and no oxycodone. ==Timeline of detections== ==Timeline of detections==