Since the dawn of human space exploration, astronauts, scientists, and engineers have examined the short- and long-term effects of microgravity (often mistakenly called zero-gravity) on the human body. This includes the distribution of fluids to the upper body (called “puffy face”), an increase in height from the spine slightly extending, how solar and cosmic radiation impacts humans at the genetic level, and skeletal and muscle loss. However, arguably all these aspects pale in comparison to how the microgravity from spaceflight impacts the heart, and specifically heart muscle cells.