Four people have been hospitalized with serious injuries following a two vehicle crash on Highway 427 early Sunday morning.Provincial police say the crash occurred in the northbound lanes of the highway at Highway 401 around 3:30 a.m.Paramedics say they transported four people to a trauma centre with injuries described as “life-altering” while a fifth person sustained minor injuries.Provincial police say one individual has injuries considered life-threatening. The was no immediate word on the circumstances leading up to the crash.