Scientists at the Center for Cell Dynamics, School of Biological and Behavioral Sciences, Queen Mary University of London, in collaboration with Carl Zeiss, have developed an innovative live-cell imaging technique that combines an exceptional resolution of 60 nanometers with fluorescence recovery after photobleaching, while significantly reducing light-induced cellular damage. This advancement allows researchers to observe intricate cellular processes with unprecedented clarity, opening new avenues for understanding fundamental biological mechanisms, including DNA repair and chromosome dynamics. The technology can also facilitate novel live-cell dynamics based drug target and drug screening methods that transcend the diffraction limit of systems.