Aging Ment Health. 2025 Jul 14:1-14. doi: 10.1080/13607863.2025.2515178. Online ahead of print.ABSTRACTTo investigate mechanisms of change and/or mediators across psychosocial research for improving the wellbeing of people with dementia. Searches were conducted from August 2023-October 2024. The CASP and MMAT Tools were used for methodological quality assessment. Thirty studies were included. Mediating variables and mechanisms of change were identified at the individual, carer and process/system-level. Some individuals' variables included physical fitness, social engagement, memories of achievements and strengths, tailored activities according to interests, controlling for pain/psychopathology, expressing anger/grief/sense of humour, being involved in the care of pets, optimism, self-esteem, positive attitude toward aging, lower subjective age, and neuroticism. Carer-level influencing variables were burden, making adaptations at home, social care knowledge, medications, support groups, dyadic coping/religiosity, relationship quality. Process/system-level variables related to having a familiar/calm/secure place, regular and outdoor activities, horse and nature connection, being in the community/socialization/connectedness, therapist knowledge of dementia care/rapport, music, arts, life-storytelling, mindfulness, reminiscence about personal strengths/achievements for present and future goal-setting, and unstructured sessions. Person-centered care for living well with dementia must be evidence-based. We provide a scientific base for planning future interventions, health/care policies, and practices, by informing therapeutic targets that may improve the wellbeing of people with dementia.PMID:40654008 | DOI:10.1080/13607863.2025.2515178