Herpes simplex virus type 1 (HSV-1) infection dramatically remodels the host cell's nuclear structures. Infection leads to the formation of viral replication compartments and to chromatin marginalization to the nuclear periphery. Joint research by the Universities of Jyväskylä (Finland) and Bar-Ilan (Israel) reveals that viral infection also alters the structure of nuclear speckles, which are essential for messenger RNA processing.