MSNBC senior medical analyst Dr. Vin Gupta has said that President Donald Trump is showing “all the signs of dementia,” in a post on X. This came after Trump posted a shocking and profane message aimed at Iran on his Truth Social account on Easter Sunday, sparking widespread discussion among politicians and former staffers, with many calling for the 25th Amendment to be invoked over concerns about the president’s fitness for office. Dr. Gupta listed several specific signs he observed in Trump’s behavior, writing that the president is “erratic,” “can’t finish sentences,” and is “often confused.” He also pointed to an “illogical train of thought” and “word finding difficulties,” noting that these symptoms have been “developing and worsening gradually over time.” Erratic. Can’t finish sentences. Often confused. Illogical train of thought. Word finding difficulties. Developing and worsening gradually over time.The President is exhibiting all the signs of dementia.— Dr. Vin Gupta (@VinGuptaMD) April 5, 2026 The Truth Social post that set off this latest wave of concern was shared on Easter Sunday, a day traditionally associated with peace and reflection. Directed at Iran, it read: “Tuesday will be Power Plant Day, and Bridge Day, all wrapped up in one, in Iran. There will be nothing like it!!! Open the F—in’ Strait, you crazy bastards, or you’ll be living in Hell – JUST WATCH! Praise be to Allah. President DONALD J. TRUMP.” Calls to invoke the 25th Amendment are coming from both sides of the political aisle The reaction was swift, with lawmakers, constitutional experts, and former administration officials openly discussing the 25th Amendment. This constitutional provision allows the vice president and a majority of the Cabinet to declare a president unable to carry out the duties of office. At this point, the vice president immediately becomes president. Even prominent Republicans raised alarm. Marjorie Taylor Greene implored Congress to “intervene in Trump’s madness,” writing, “I know all of you and him and he has gone insane, and all of you are complicit.” White House correspondent S.V. Dáte noted that “‘He has gone insane.’ That would be 25th Amendment territory.” Questions have also been raised about who is financially benefiting from the Iran conflict at the cost of American lives, adding another layer of scrutiny to the administration’s handling of the situation. Democrats were more direct. Representative Yassamin Ansari (D-AZ) wrote, “The 25th Amendment exists for a reason. The President of the United States is a deranged lunatic, and a national security threat to our country and the rest of the world.” If I were in Trump's Cabinet, I would spend Easter calling constitutional lawyers about the 25th Amendment.This is completely, utterly unhinged. He's already killed thousands. He's going to kill thousands more. pic.twitter.com/vB0TAp3RuK— Chris Murphy (@ChrisMurphyCT) April 5, 2026 Senator Chris Murphy (D-CT) stated, “If I were in Trump’s Cabinet, I would spend Easter calling constitutional lawyers about the 25th Amendment. This is completely, utterly unhinged. He’s already killed thousands. He’s going to kill thousands more.” Several former Trump staffers also spoke out. Miles Taylor responded to Senator Murphy’s post by writing, “Yes. He’s pledging war crimes. It’s time for the 25th.” Former White House Communications Director Anthony Scaramucci wrote, “It was at this point that our Founders thought the best thing to do would be to remove a mad man who has the executive office. It became more formalized with the 25th amendment, but more people now should be calling for this man’s removal.” Former Republican Representative Joe Walsh (R-IL) also called for the amendment’s invocation, writing, “He will forever be a stain on this country. And the world. 25th Amendment. Now.” Representative Melanie Stansbury (D-NM) declared, “The emperor has no clothes. Time for the #25thAmendment. Congress and the Cabinet must act.” Ironically, Trump himself joked about the 25th Amendment just weeks earlier. At a press conference on March 26, when asked about his plans regarding Iran, he laughingly asked, “what is it called, the 25th Amendment?” and added, “They’d institute the 25th Amendment,” before remarking, “Which they didn’t do with Biden, which is shocking.” That casual joke has now become a serious topic of national debate, particularly after Trump backed down from his Iran bombing threats and was forced to negotiate instead. These discussions are also unfolding against a backdrop of low public support for the ongoing conflict with Iran.