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Nat Cell Biol. 2023;25:528–39.Google Scholar Download referencesAcknowledgementsSpecial thanks to Catherine Fisher for English language editing.FundingThis work was supported by FISR2019_00374 MeDyCa-B84G19000200008; MUR-Prin:CW39SJ; B53D23025100001; P2022-5KJ5L; A93K7S; P2022FESRR; AIRC grants: IG32565, IG26172 and IG31139;MIMIT–DM 31/12/2021 EPIGA;NABUCCO F/260018/03/X51-CUP: B29J24001270005; EPI-MET F/310034/03/X56; DARIA - CUP: B73C22001250006; and National Plan for NRRP Complementary Investments–Law Decree 6 May 2021, no. 59, converted and modified as to Law no. 101/2021 Research initiatives for technologies and innovative trajectories in the health and care sectors–ANTHEM (AdvaNced Technologies for Human centrEd Medicine). e-DAY: Ecosistema digitale per analisi integrate di dati sanitari eterogenei relative a patologie ad alto impatto: T2-AN-21 Ministero della Salute. GS was supported by post-doctoral fellowship received by PNRR-Missione 4-2, “Dalla ricerca all’impresa” Nextgeneration MEDUSA CUP B83C2200068007.Author informationAuthors and AffiliationsDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, Naples, ItalyGiulia Sgueglia, Crescenzo Massaro, Annamaria Muro, Ida Lettiero, Erika D’Agostino, Gregorio Favale, Nicla Simonelli, Nunzio Del Gaudio, Vincenzo Carafa, Lucia Altucci & Carmela Dell’AversanaDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the NetherlandsCrescenzo MassaroLink Campus University, Rome, ItalyNunzio Del GaudioBIOGEM, Ariano Irpino, ItalyVincenzo Carafa & Lucia AltucciDepartment of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, SwedenTommaso De MarchiDepartment of Science, “Roma Tre” University, Rome, ItalyDante RotiliBiostructures and Biosystems National Institute (INBB), Rome, ItalyDante RotiliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, ItalySergio Valente & Antonello MaiDepartment of Pharmacy, Epigenetic Med Chem Lab, University of Salerno, Fisciano, ItalyGianluca SbardellaDivision of Hematology, AORN Cardarelli, Naples, ItalyMariacarla De SimoneMedical Epigenetics program, Vanvitelli Hospital, Naples, ItalyLucia AltucciInstitute of Endotypes in Oncology, Metabolism, and Immunology ‘G. Salvatore’ (IEOMI) -National Research Council (CNR), Naples, ItalyCarmela Dell’AversanaDepartment of Medicine and Surgery, LUM University, Casamassima, ItalyCarmela Dell’AversanaAuthorsGiulia SguegliaView author publicationsSearch author on:PubMed Google ScholarCrescenzo MassaroView author publicationsSearch author on:PubMed Google ScholarAnnamaria MuroView author publicationsSearch author on:PubMed Google ScholarIda LettieroView author publicationsSearch author on:PubMed Google ScholarErika D’AgostinoView author publicationsSearch author on:PubMed Google ScholarGregorio FavaleView author publicationsSearch author on:PubMed Google ScholarNicla SimonelliView author publicationsSearch author on:PubMed Google ScholarNunzio Del GaudioView author publicationsSearch author on:PubMed Google ScholarVincenzo CarafaView author publicationsSearch author on:PubMed Google ScholarTommaso De MarchiView author publicationsSearch author on:PubMed Google ScholarDante RotiliView author publicationsSearch author on:PubMed Google ScholarSergio ValenteView author publicationsSearch author on:PubMed Google ScholarAntonello MaiView author publicationsSearch author on:PubMed Google ScholarGianluca SbardellaView author publicationsSearch author on:PubMed Google ScholarMariacarla De SimoneView author publicationsSearch author on:PubMed Google ScholarLucia AltucciView author publicationsSearch author on:PubMed Google ScholarCarmela Dell’AversanaView author publicationsSearch author on:PubMed Google ScholarContributionsGS performed most cellular and molecular experiments and wrote the manuscript. CM, AM, ED, and NS performed some of the molecular and cell-based experiments. IL and TDM contributed to both the methodological setup and analysis using LC-MS/MS; VC and GF performed some cell-based experiments; GS, DR, SV and AM contributed by synthesizing and supplying the chemical compounds. MDS provided patient specimens/data; NDG contributed to the design and editing of manuscript; LA and CD were responsible for acquisition of funding, project conceptualization and supervision, data interpretation, writing the review, and editing. All authors read and approved the manuscript.Corresponding authorsCorrespondence to Lucia Altucci or Carmela Dell’Aversana.Ethics declarationsCompeting interestsThe authors declare no competing interests.Additional informationPublisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Edited by Dr Gerry MelinoSupplementary informationSupplementary Figures (download DOCX )Supplementary Methods (download DOCX )Supplementary Information (download PDF )Data Set 2 (download PDF )Rights and permissionsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 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