England host Uruguay at Wembley Stadium on Friday night as Thomas Tuchel hopes to fine tune his tactics with the 2026 World Cup on the horizon.Tuchel has chosen a squad of 35 ahead of this international friendly double header against Uruguay and Japan. The England manager has given the opportunity for players to ‘earn their plane tickets’ to North America in June.Uruguay will present a tough test and an opportunity to play a team from south America ahead of potential opponents in the knockout rounds this summer.England v Uruguay best betsEngland to win both halves – (was 11/4) NOW 3/1 with Boyle SportsBoth teams to score – 11/10 with Sky BetBet builder: BTTS & Under 2.5 goals – 13/2 with Sky BetEngland v Uruguay betting tips, predictions, team news and how to watchEngland v Uruguay latest oddsFind the latest England v Uruguay betting odds here, courtesy of Sky Bet and are subject to change.England – 4/9Draw – 13/5Uruguay – 17/4England v Uruguay predictionThere’s not much to go at in terms of head-to-head fixtures with these latest squads. The last time the two nations locked horns was in the World Cup 2014 as Uruguay won 2-1. Before that England won 2-1 in another March international friendly ahead of the 2006 World Cup.Recent form of both sides suggests England should win this though. The Three Lions were rampant in their qualifying group. Winning all eight matches, scoring 22 goals without conceding.Tuchel will shuffle the pack, with those World Cup ‘golden tickets’ up for grabs. He’s drafted Ben White back into the squad, so to Harry Maguire and given a first call-up to Harvey Barnes. Plus Everton’s James Garner for his first opportunity in the national team too.But he will have to cut his 35-strong squad down to 24 before the match. Although regulars Harry Kane, Declan Rice, Bukayo Saka, Marc Guehi, Carabao Cup hero Nico O’Reilly and Elliott Anderson will be rested for this one.Nonetheless, the last time England played a team inside the top 20 of the FIFA World Rankings, they lost. Senegal (14th) ran out 3-1 winners at Nottingham Forest’s City Ground, humbling Tuchel’s men.Uruguay in 17th will be a mental hurdle for this England team to overcome. The highest ranked nation they played in their qualifying group was 39th ranked Serbia, who they thrashed 5-0 in Belgrade.Bielsa’s side may not be the same without Luis Suarez and Edinson Cavani. Their attacking thrust may come from Real Madrid’s Federico Valverde and Flamengo’s Giorgian De Arrascaeta.Former Liverpool striker Darwin Nunez is in the squad, but he hasn’t played a match for new club Al Hilal since mid February. He was de-registered for Saudi Pro League matches after the club bought in Karim Benzema in the January transfer window.They’ve been good on home soil over the last year. But their away form leaves much to be desired, not winning a competitive game outside of Uruguay since a penalty shoot-out victory against Canada in the 2024 Copa America.In their last outing, they were thrashed 5-1 by USA in November. A response will be demanded from Bielsa. Can they cause an upset at Wembley?England v Uruguay betting tipsEngland to win both halves – (was 11/4) NOW 3/1 with Boyle SportsEngland haven’t lost a game since June 2025, that’s a seven game win streak without conceding a goal. Crucially to this bet, they’ve scored in both halves in four of these seven matches.Uruguay come into this match in patchy form, still searching for a winning formula. There will be plenty of England players champing at the bit to impress Tuchel. Which should mean there’s a lot of goal-mouth action from kick off. Both teams to score – 11/10 with Sky BetWhile the new players in the England squad will provide a renewed cut and thrust it could destabilize the side from a defensive aspect. Uruguay still have some dangerous attackers and Nunez may well get some minutes. Which would be his first appearance in over a month. With the regulars not featuring for England it could present some goal-scoring opportunities for Uruguay.Bet builder: BTTS & Under 2.5 goals – 13/2 with Sky BetBoth sides will be shuffling the pack and giving opportunities to players as both Tuchel and Bielsa begin to shape the squads they will take to the World Cup.It might prove a disjointed match but an entertaining one, which is edged by the odd goal.England v Uruguay predicted lineupsEngland (4-2-3-1): Pickford; Hall, Konsa, Maguire, White; Mainoo, Henderson; Madueke, Palmer, Rashford; Calvert-LewinUruguay (4-4-2): Mele; Varela, Gimenez, R. Araujo, Vina; Nandez, Valverde, Ugarte, De Arrascaeta; Vinas, M. AraujoHow to watch England v UruguayLocation: Wembley Stadium, London, UKDate and time: Friday 27th March 2026, 7:45pmHow to watch: ITV 1, STV, ITVxMore International football predictionsFind more predictions and betting tips from our expert punters in our match previews on the Champions League, Premier League, Championship, League One and more!Commercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. 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