Manchester United take on Burnley in the Premier League on Saturday afternoon at Old Trafford still searching for their first win of the season.Manchester United v Burnley best betsBenjamin Sesko to score at 6/5 with LadbrokesManchester United to win to nil at 11/8 with SBKManchester United v Burnley latest oddsFind the latest Manchester United v Burnley betting odds here, odds courtesy of SBK and are subject to change.Manchester United – 2/5Draw – 43/10Burnley – 38/5Manchester United v Burnley predictionsManchester United are eager to return to the field and redeem themselves after a stunning Carabao Cup upset on Wednesday, where they suffered a defeat against League Two’s Grimsby Town.Ruben Amorim faces mounting scrutiny over his position, with the team yet to secure a victory in their first three matches across all competitions this season. They head into the weekend with just one point from their opening two Premier League games.The Red Devils kicked off the campaign with a loss at home to Arsenal, followed by a 1-1 draw against Fulham at Craven Cottage, positioning them 16th in the league table, only goal difference keeping them above the relegation zone.Despite Manchester United’s struggles, Burnley, newly promoted from the Championship, will arrive at Old Trafford as underdogs. Promoted teams have often found the Premier League challenging in their first season back, as seen in recent years.After an opening 3-0 defeat to Tottenham, Scott Parker’s Burnley have bounced back with two consecutive victories across all competitions. A 2-0 league win against Sunderland last week has them in the top half of the table with three points from two matches.On Tuesday, the Clarets secured a spot in the Carabao Cup’s third round with a 2-1 home win over Championship side Derby, sealed by a 91st-minute goal from right-back Oliver Sonne. With two wins in a row, Burnley head to Old Trafford with confidence to face a vulnerable Manchester United.The Red Devils have not lost to Burnley in their last seven encounters, though their most recent clash at Old Trafford ended in a 1-1 draw. Burnley have only triumphed once at the ‘Theatre of Dreams’ in the past 63 years.Despite their current fragility, Manchester United should be able to record their first win of the campaign on Saturday afternoon against a newly promoted Burnley side – a 2-0 home win seeming a safe bet.Manchester United v Burnley betting tipsRed Devils to get off the markBurnley should be ideal opponents for Manchester United to pick up their first win of the season at Old Trafford with Ruben Amorim under pressure for his job, with the Clarets having won only once away against United in 63 years.The Clarets were well beaten 3-0 by Tottenham on the opening game of the season and their poor record at Old Trafford suggests they may struggle on Saturday too.Manchester United to win to nil at 11/8 with SBKSesko to get off the markIt’s looking like Benjamin Sesko will be making his full Premier League debut on Saturday following his £66m move from Leipzig, with Manchester United’s only goal in the league this season far being an own goal.The Slovenian scored 39 goals across his two seasons in Germany and will be looking to hit the ground running in the Premier League on Saturday in front of his home fans.Benjamin Sesko to score at 6/5 with LadbrokesManchester United v Burnley predicted lineupsManchester United (3-4-3): Bayindir (GK); Yoro, de Ligt, Shaw; Diallo, Fernandes, Casemiro, Dorgu; Mbeumo, Sesko, CunhaBurnley (4-2-3-1): Dubravka (GK); Walker, Ekdal, Esteve, Hartman; Cullen, Ugochukwu; Larsen, Mejbri, Anthony; FosterHow to watch Manchester United v BurnleyLocation: Old Trafford, ManchesterDate and time: Saturday 29th August 2025, 3pmHow to watch: Not available on UK TVMore Premier League predictionsFind more predictions and betting tips from our expert punters in our match previews on the Premier League, Championship, League One and more!Commercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. GambleAware.orgRemember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamcare – www.gamcare.org.ukGambleAware – www.gambleaware.orgFind our detailed guide on responsible gambling practices here.For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.Free Bet OffersSee all the best free bets and betting offers available in the UK over at our dedicated pageSee all free bets18+ gambleaware.org. T&Cs apply