by Peihua Wang, Xianwen Wang, Wenyi Zhang, Yong Wang, Sen Pei, Xiao-Ke Xu, Wan YangDespite sustained high routine childhood vaccination coverage, measles outbreaks have persisted across Provincial-Level Administrative Divisions (PLADs) in China. Epidemiological evidence suggests that migrant workers substantially contribute to these outbreaks. In this study, we investigated the role of inter-PLAD rural-to-urban migrant workers, who originate from less developed rural regions with potentially lower vaccination coverage and are employed in urban centers, in contributing to measles epidemics in China from 2005 to 2014. We developed a networked metapopulation Susceptible–Exposed–Infectious–Recovered model that incorporated migrant worker mobility around Chinese New Year (CNY) migration periods and year-round general-purpose traveler mobility. By simulating measles transmission dynamics within migrant worker subpopulations, we identified key epidemiological connections between origin and host PLADs. In northern China, migrant workers from Hebei and Shandong were the key contributors to outbreaks in two northern host PLADs, Beijing and Tianjin. In southern China, migrant workers from Anhui and Sichuan were the key contributors across multiple southern host PLADs. Counterfactual modeling suggests that measles epidemics in host PLADs were sustained by susceptibility replenishment through inflows of under-vaccinated migrant workers during the CNY migration periods. Moreover, epidemics in origin PLADs might have been synchronized and facilitated by case importation of exposed and infectious migrant workers returning from endemic host PLADs, and the strength of this seeding effect depended on the volume of migrant worker flows. Traveler mobility showed minimal impact on measles epidemics. Counterfactual modeling of pre-migration vaccination with coverage ranging from 25% to 100% showed national incidence reduction from 33.0% to 50.9%, with significant reduction in host PLADs, and in turn in origin PLADs due to weakened seeding effect. Our findings provide mechanistic insights into the epidemiological role of rural-to-urban migrant workers in measles epidemics, which could support targeted vaccination strategies for improved measles control in China and regions with similar migration dynamics.