Barcelona and Atletico Madrid faced off in La Liga on Saturday and the Spanish duo will do it all again on Wednesday, this time in the first leg of their Champions League quarter-final.Will home advantage help Barcelona to establish a first-leg lead, or can Atletico get something from their latest trip to Catalonia?Barcelona with a -1.5 handicap – 6/5 with 247BetBarcelona to score in both halves – 10/11 with MidniteRobert Lewandowski to score any time – evens with Sky BetBarcelona vs Atletico Madrid oddsFind the latest Barcelona vs Atletico Madrid betting odds here. All odds are provided by our recommended football bookmakers and are subject to change.Barcelona vs Atletico Madrid predictionsTake two. Barcelona and Atletico Madrid met as recently as Saturday night, when the former took a giant step closer to the La Liga title with a 2-1 victory at the Riyadh Air Metropolitano.Now the two teams are poised to do it all again, this time at the Camp Nou in the Champions League. Barcelona will host the first leg of this quarter-final, before the tie reaches a conclusion in the Spanish capital next week.What, if anything, can we learn from Saturday’s showdown? Atletico took the lead in the 39th minute last time out, as Giuliano Simeone put his father’s team ahead.They were not in front for long, however, as Marcus Rashford restored parity in the 42nd minute. Then came the game-changing moment: deep into first-half stoppage time, Atletico had Nico Gonzalez sent off for denying Lamine Yamal a goalscoring opportunity.With their numerical advantage Barcelona came on strong after the interval, and Robert Lewandowski notched the winner late on.It was a significant victory for Hansi Flick’s side. Real Madrid had unexpectedly lost 2-1 to Real Mallorca earlier in the day, so Barca’s success moved them seven points clear at the top of the table.The title race is not over yet, but even Madrid fans know it is highly unlikely that their team will be crowned champions from here.“We controlled the match,” Flick said afterwards. “These are three very important points. There are eight games left, nothing is done and we have to do our job.”Atletico will take heart from the fact the game was pretty even up until the red card, and that they only lost to a late Lewandowski goal. In many ways Diego Simeone’s men showed they are ready to compete with Barcelona over two legs.At the same time, the Blaugrana will be confident of getting the better of Atletico over 180 minutes. They may have recently suffered an aggregate defeat by the same opponents in the Copa del Rey, with Atletico winning 4-0 at home before losing 3-0 away, but the La Liga table shows that Barcelona have been the better team over the course of the campaign. Anything can happen in a knockout tie, though, and once the referee’s whistle begins the contest on Wednesday night, Saturday’s game will count for nothing.Barcelona vs Atletico Madrid betting tipsBarcelona host La Liga rivals Atletico Madrid in the Champions League on Wednesday night.Barca too strongIn that aforementioned Copa del Rey tie, Atletico Madrid made the most of having the first leg at home by winning 4-0 on familiar soil.Barcelona will be looking to do something similar here. The Metropolitano is a difficult place to go, so Flick will want to take a healthy lead to Madrid next week.We expect Barcelona to hold at least a two-goal advantage at the midway point of this tie. Atletico are not the defensive force they once were, while Barca are well versed in breaking deep defences of the sort Simeone is likely to use on Wednesday. A victory by two clear goals is well within reach for the Catalans. Go for Barcelona with a -1.5 handicap at 6/5 with 247Bet Barca attack to sparkleBarcelona found the back of the net either side of the interval on Saturday and there is a decent chance they will repeat the feat here.Flick’s side are one of the most potent attacking forces in the whole of Europe. Barca are averaging 2.67 goals per game in La Liga this term, and a remarkable 3.1 per match in Europe.As mentioned above, Atletico Madrid are not as solid as they once were. Simeone’s men have conceded 15 goals in their last seven matches in all competitions, keeping just one clean sheet in that time.Barcelona have the attacking quality to score in both halves, particularly at the Camp Nou. Back Barcelona to score in both halves at 10/11 with Midnite Lewandowski’s time to shineLewandowski was the hero on Saturday, coming off the bench to score Barcelona’s winning goal.The Poland international has to be managed carefully now he is 37, but he will almost certainly be in the starting XI on Wednesday.Only Cristiano Ronaldo and Lionel Messi have scored more goals in Champions League history than Lewandowski, who has made the net bulge 109 times in this competition. The Poland international can add another strike to his impressive tally when Atletico Madrid head to Catalonia. Select Robert Lewandowski to score any time at evens with Sky Bet Barcelona vs Atletico Madrid predicted lineupsBarcelona expected lineup: J. Garcia; Kounde, Cubarsi, Martin, Cancelo; Casado, Pedri; Yamal, Lopez, Raphinha; Lewandowski.Atletico Madrid expected lineup: Musso; Molina, Le Normand, Lenglet, Gonzalez; Simeone, Koke, Vargas, Lookman; Alvarez, Sorloth. Where to watch Barcelona vs Atletico MadridLocation: Camp Nou, Barcelona, Spain.Date and time: Wednesday 8th April, 8pm.How to watch: TNT Sports 2.More Champions League predictionsWe have plenty more Champions League predictions and picks – find our latest betting tips from expert punters in our match preview overview.About the authorGreg LeaGreg Lea is a freelance football writer from London. He predominantly covers the Premier League and has had work published by the Guardian, FourFourTwo, ESPN and others.Follow Greg on X: @GregLeaFootballCommercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. 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