A Tottenham Hotspur defender, who has started both of their games under Roberto De Zerbi so far, is a doubt for the clash against Wolves after suffering a fresh injury.Tottenham desperately need a win to boost their chances of survival as they head to the Molineux Stadium to face the side sitting at the bottom of the table.Wolves have now officially been relegated from the Premier League, and De Zerbi will be hoping third time is the charm after picking up just one point in his first two games in charge of the Lilywhites.However, his side has now been handed yet another major injury blow ahead of their trip to the West Midlands.Credit: @reclusemedia / InstagramDestiny Udogie may miss Tottenham’s clash against WolvesThe Sun have now revealed that Destiny Udogie is the latest Spurs star to succumb to an injury ahead of their big clash on Saturday.The Italian has had a number of fitness issues over the last two seasons, including knee and hamstring problems.The left-back only returned to action from his most recent hamstring problem last month, but he has now suffered another setback.While the nature of Udogie’s latest injury is unknown, he has been deemed a doubt for Saturday’s clash, which means that Djed Spence could be in line for his first start under De Zerbi.Two other senior Spurs stars could return against WolvesWhile Udogie’s absence would be a major blow for the Lilywhites, they could be boosted by the return of two of their senior men this Saturday.The Standard have claimed that James Maddison and Guglielmo Vicario could be in line to feature against Wolves.Vicario has missed Tottenham’s last two games after undergoing a hernia operation, while Maddison was named in the matchday squad for the first time against Brighton, having missed the entirety of the season so far due to an ACL injury he suffered last summer.READ MORE: Tottenham set Cristian Romero price tag, but it contradicts what his dad said about release clause valueThe post Tottenham suffer fresh injury blow to key starter ahead of Wolves clash appeared first on Spurs Web.