Premier League games do not get much bigger than this. It is second against first at the Etihad Stadium this weekend, as these two title rivals go head-to-head in what could be a decisive fixture.Will City close the gap between the pair to three points, or can Arsenal extend their lead at the summit of the standings? Buckle up for a mouthwatering contest.Manchester City to win – 5/6 with 247BetManchester City to score over 1.5 goals – 20/23 with BoyleSportsRayan Cherki to score or assist – 11/8 with Sky BetManchester City vs Arsenal oddsFind the latest Manchester City vs Arsenal betting odds here. All odds are provided by our recommended football bookmakers and are subject to change.Manchester City vs Arsenal predictionsA glance at the Premier League table would appear to suggest the pressure is all on Manchester City this weekend.After all, Pep Guardiola’s men trail Arsenal by six points as the title race nears a conclusion. Granted, City have a game in hand on the north Londoners, but most teams would rather have points in the bag at this stage of the campaign.Both sides are in similar form in the league. City have collected 14 points from the last 18 available, while Arsenal have amassed 13. If we look at results since the turn of the year, the Gunners have outperformed City by a point.And yet despite all that, Arsenal are the team under scrutiny – and understandably so. Having looked home and dry a few weeks back, Mikel Arteta’s team are in danger of throwing all their hard work away.Recent history is one reason why the pressure is on Arsenal. This is a side which has finished as runners-up in three consecutive campaigns. This season was supposed to be the one where Arsenal finally got over the line. Another reason is the shift in momentum. True, Arsenal have picked up points at a comparable rate to City of late. But there have also been hugely disappointing moments for Arteta and co. in the spring, none more so than last month’s EFL Cup final.Arsenal went into that showpiece event against Manchester City as the favourites. It was a golden chance for this group of players to both lay down a marker against Guardiola’s men, and to claim their first piece of silverware.Instead, Arsenal fell to the occasion. After an even first half, City took the game away from them after the break. They were worthy winners in the end.Arsenal then exited the FA Cup at the hands of Championship outfit Southampton, before going down 2-1 at home to Bournemouth on their return to Premier League action last weekend. A few days later, an unconvincing 0-0 draw with Sporting CP sent Arsenal through to the semi-finals of the Champions League, but their flat performance did not make their fans feel any better.Nerves have set in at Arsenal, whereas City are coming on strong in the run-in as they have done numerous times before. Still, an away win on Sunday would in effect hand the title to Arsenal. What an incentive that is.Manchester City vs Arsenal betting tipsWill Manchester City or Arsenal triumph in this mouthwatering Premier League clash?Home team to triumphArsenal are good enough to beat any team in Europe on their day, including Manchester City. But the evidence of the last few weeks points only in one direction as far as this match is concerned.Guardiola’s side have the bit between their teeth. Arsenal, it is fair to say, do not. That could make all the difference.A draw would be a good result for Arteta’s team. But even that complicates the situation somewhat. City need to win, so there is no danger of them being caught in two minds.Arsenal have not triumphed at the Etihad Stadium since Arsene Wenger oversaw a 2-0 win in January 2015. A ninth defeat since then beckons on Sunday. Back Manchester City to win at 5/6 with 247Bet Two goals for CityGuardiola is a master at finding solutions to problems. A tactical innovator like few others, he has come up with yet another setup over the last few weeks.Namely, the Manchester City manager has come up with a way to fit Erling Haaland, Jeremy Doku, Rayan Cherki, Antoine Semenyo and Bernardo Silva in the same XI.Silva has been pulled deeper alongside Rodri in midfield, leaving Semenyo, Cherki and Doku to cause mischief behind Haaland.With that system, City have scored two goals against Arsenal, four against Liverpool and three against Chelsea. Expect at least another two in this one. Select Manchester City to score over 1.5 goals at 20/23 with BoyleSports Cherki in fine formManchester City’s return to form has been a collective effort. As well as scoring plenty of goals, they have kept three clean sheets on the bounce against top-six opponents.Yet Rayan Cherki has contributed more than most to the revival. The France international is a genuine maverick and Guardiola has given him the license to improvise in his No.10 role.Cherki oozes creativity, as we saw when he set up two of City’s goals in the 3-0 defeat of Chelsea last time out.The former Lyon man has had a direct hand in three goals in his last two appearances. He is bound to have an influence on this weekend’s match too. Choose Rayan Cherki to score or assist at 11/8 with Sky Bet Manchester City vs Arsenal predicted lineupsManchester City expected lineup: Donnarumma; Nunes, Khusanov, Guehi, O’Reilly; Rodri, Silva; Semenyo, Cherki, Doku; Haaland.Arsenal expected lineup: Raya; Mosquera, Saliba, Gabriel, Hincapie; Zubimendi, Rice; Madueke, Eze, Martinelli; Gyokeres. Where to watch Manchester City vs ArsenalLocation: Etihad Stadium, Manchester, England.Date and time: Sunday 19th April, 4.30pm.How to watch: Sky Sports Main Event and Sky Sports Premier League.More Premier League predictionsWe have plenty more Premier League predictions and picks – find our latest betting tips from expert punters in our match preview overview.About the authorGreg LeaGreg Lea is a freelance football writer from London. He predominantly covers the Premier League and has had work published by the Guardian, FourFourTwo, ESPN and others.Follow Greg on X: @GregLeaFootballCommercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply.Remember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamcare – www.gamcare.org.ukFind our detailed guide on responsible gambling practices here.For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.Most read in BettingIpswich Town v Middlesbrough betting tips and predictions, how to watch, team newsEverton v Liverpool odds boosts: Get 50% back up to £50 in free bets with QuinnBetITV Racing Tips and Previews (Saturday 18th April 2026)Sidemen FC vs YouTube Allstars odds, betting preview and £30 in free bets with bet365Newcastle United vs Bournemouth predictions and betting tips - Magpies aim to stop rotNottingham Forest vs Burnley betting offer: Bet £5 get £30 in free bets on SBK