News & ViewsPublished: 02 January 2026Hematopoietic stem cell agingChih-Ling Wang ORCID: orcid.org/0000-0002-0836-50261 &Mary Mohrin1 Nature Aging (2026)Cite this articleSubjectsAgeingNuclear envelopeTwo recent studies, from Shang et al. and Mejía-Ramírez et al., identify complementary mechanical mechanisms that regulate hematopoietic stem cell aging: external shear stress and internal nuclear envelope tension. These forces represent an evolutionary tradeoff between immediate immune defense and long-term stem cell maintenance.This is a preview of subscription content, access via your institutionAccess optionsAccess Nature and 54 other Nature Portfolio journalsGet Nature+, our best-value online-access subscription27,99 € / 30 dayscancel any timeLearn moreSubscribe to this journalReceive 12 digital issues and online access to articles118,99 € per yearonly 9,92 € per issueLearn moreRent or buy this articlePrices vary by article typefrom$1.95to$39.95Learn morePrices may be subject to local taxes which are calculated during checkoutFig. 1: Increased shear stress and nuclear envelope tension drive HSC aging.ReferencesShang, T. et al. Nat. Aging https://doi.org/10.1038/s43587-025-01039-1 (2026).Article Google Scholar Mejía-Ramírez, E. et al. Nat. Aging https://doi.org/10.1038/s43587-025-01014-w (2025).Article PubMed Google Scholar Fotopoulou, F., Rodríguez-Correa, E., Dussiau, C. & Milsom, M. D. Exp. Hematol. 143, 104698 (2025).Article CAS PubMed Google Scholar Kasbekar, M., Mitchell, C. A., Proven, M. A. & Passegué, E. Cell Stem Cell 30, 1403–1420 (2023).Article CAS PubMed PubMed Central Google Scholar Ross, J. B. et al. Nature 628, 162–170 (2024).Article CAS PubMed PubMed Central Google Scholar Mohrin, M. et al. Science 347, 1374–1377 (2015).Article CAS PubMed PubMed Central Google Scholar Song, Z. et al. Nat. Aging 4, 1384–1393 (2024).Article CAS PubMed PubMed Central Google Scholar Guderyon, M. J. et al. Aging Cell 19, e13110 (2020).Article CAS PubMed PubMed Central Google Scholar Cain, T. L., Derecka, M. & McKinney-Freeman, S. Nat. Rev. Mol. Cell Biol. 26, 32–50 (2025).Article CAS PubMed Google Scholar Méndez-Ferrer, S., Lucas, D., Battista, M. & Frenette, P. S. Nature 452, 442–447 (2008).Article PubMed Google Scholar Cheshier, S. H., Prohaska, S. S. & Weissman, I. L. Stem Cells Dev. 16, 707–717 (2007).Article CAS PubMed Google Scholar Massberg, S. et al. Cell 131, 994–1008 (2007).Article CAS PubMed PubMed Central Google Scholar Deng, J. et al. Discov. Oncol. 16, 787 (2025).Article CAS PubMed PubMed Central Google Scholar Ho, T. T. et al. J. Exp. Med. 218, e20210223 (2021).Article CAS PubMed PubMed Central Google Scholar Young, K. et al. Cell Stem Cell 28, 1473–1482 (2021).Article CAS PubMed PubMed Central Google Scholar Download referencesAcknowledgementsWork in the Mohrin Lab is supported by a COBRE grant from NIGMS (P20GM121327), a NCI supported pilot grant from the Markey Cancer Center (MCC) and the Substance Use Priority Research Area (SUPRA), and administratively supported by NCI Cancer Center Support Grant (P30 CA177558).Author informationAuthors and AffiliationsDepartment of Toxicology & Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY, USAChih-Ling Wang & Mary MohrinAuthorsChih-Ling WangView author publicationsSearch author on:PubMed Google ScholarMary MohrinView author publicationsSearch author on:PubMed Google ScholarContributionsC.-L.W. drafted the initial manuscript and M.M. provided key conceptual input and contributed to manuscript revisions. C.-L.W. and M.M. revised the final draft and approved the submission.Corresponding authorCorrespondence to Mary Mohrin.Ethics declarationsCompeting interestsThe authors declare no competing interests.Rights and permissionsReprints and permissionsAbout this article