3 Biotech Stocks That Could More Than Triple if Their Trials Succeed

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RegExp("[?&]notifications=1(&|#|$)");"desktop"===y&&i&&b.test(window.location.search)&&(i.checked=!0)};ge("ybar-mod-notification",(function(e){var t={isUH3:"crunch"===e.getConfig().ytheme,notifContainer:document.getElementById("notification-container"),notifBadge:document.getElementById("notif-badge"),notifMenu:document.getElementById("ybarNotificationMenu"),notifMenuOpener:document.querySelector("#ybarNotificationMenu + label"),notifDropdown:document.getElementById("notifDropdownContainer"),tooltipContainer:document.querySelector(".".concat($n)),notifLabel:document.querySelector(".".concat(Xn))};t.notifDropdown&&so(e,t)}))}()}};]]>Sushree MohantySat, October 11, 2025 at 6:00 PM GMT+2 5 min readBiotech investing is often a high-risk, high-reward game, with clinical trial results capable of sending stocks soaring or plummeting. For investors willing to bet on scientific breakthroughs, these three companies with intriguing pipelines have the potential to generate massive rewards if their trials are successful.The first on the list is Astria Therapeutics (ATXS), a clinical-stage biotech company dedicated to developing innovative therapies for rare allergic and immunologic diseases.When The Market Structure Breaks: How To Survive The Next PhaseNetflix Stock Still Looks 15% Too Cheap, Especially If It Keeps Producing 20% FCF MarginsThe Saturday Spread: Use Distributional Bifurcation to Roadmap Your Options TradesStop Missing Market Moves: Get the FREE Barchart Brief – your midday dose of stock movers, trending sectors, and actionable trade ideas, delivered right to your inbox. Sign Up Now!Valued at $476.9 million, Astria stock is down 7.3% year-to-date, compared to the broader market gain of 13%.www.barchart.comThe company currently has no approved products. However, its lead program, navenibart, is a monoclonal antibody inhibitor of plasma kallikrein. It is currently in Phase 3 clinical studies for the treatment of hereditary angioedema (HAE), a rare genetic condition that causes recurring and unpredictable swelling episodes. Astria expects to receive top-line results from the ALPHA-ORBIT Phase 3 trial in early 2027. Astria has also collaborated with Kaken Pharmaceutical on the development and commercialization of navenibart in Japan.In the second quarter, research and development expenses rose to $25.9 million, reflecting higher costs related to Navenibart’s Phase 3 trial and other pipeline efforts. As a result, Astria recorded a net loss of $33.1 million in the quarter, or $0.57 per share. At the end of Q2, Astria had cash, cash equivalents, and short-term investments totaling $259.2 million, which included the Kaken upfront payment and estimated Phase 3 cost reimbursements. This strong financial position is intended to support Astria’s operating plan through 2028, which includes the completion of the ALPHA-ORBIT and ORBIT-EXPANSE trials for navenibart, as well as the ongoing Phase 1a trial for STAR-0310.Overall, the consensus for Astria stock is a “Strong Buy.” Among the 10 analysts covering the company, nine give it a “Strong Buy” rating, and one suggests holding. The average price target of $29.89 indicates potential 253.7% upside from current levels. Meanwhile, the high price target of $49 implies the stock could surge by as much as 479.8% over the next year.Terms and Privacy PolicyPrivacy & Cookie SettingsMore InfoS&P Futures6,678.75 +83.50 (+1.27%)Dow Futures46,110.00 +404.00 (+0.88%)Nasdaq Futures24,819.75 +422.75 (+1.73%)Russell 2000 Futures2,448.40 +39.90 (+1.66%)VIX21.66 +5.23 (+31.83%)Gold4,064.10 +63.70 (+1.59%)PortfolioSign in to access your portfolioSign inTop gainersPTGX Protagonist Therapeutics, Inc. 87.00 +19.96 (+29.77%)APLD Applied Digital Corporation 33.99 +4.70 (+16.05%)NAMS NewAmsterdam Pharma Company N.V. 37.05 +4.04 (+12.26%)FRMI Fermi Inc. 29.08 +2.31 (+8.63%)MP MP Materials Corp. 78.34 +6.05 (+8.37%)Top losersVG Venture Global, Inc. 9.45 -3.13 (-24.88%)DGNX Diginex Limited 24.93 -6.46 (-20.58%)CORT Corcept Therapeutics Incorporated 73.96 -14.40 (-16.30%)WRD WeRide Inc. 10.17 -1.80 (-15.04%)AMBA Ambarella, Inc. 72.88 -11.40 (-13.53%)Most activeNVDA NVIDIA Corporation 183.05 -9.46 (-4.91%)BBAI BigBear.ai Holdings, Inc. 7.22 -0.27 (-3.60%)BITF Bitfarms Ltd. 4.2000 +0.0300 (+0.72%)INTC Intel Corporation 36.33 -1.47 (-3.89%)PLUG Plug Power Inc. 3.4200 -0.3600 (-9.52%)Earnings eventsMy earnings eventsEarnings eventsTrending tickersNQ=F Nasdaq 100 Dec 25 24,819.75 +422.75 (+1.73%)BTC-USD Bitcoin USD 115,542.16 +5,146.12 (+4.66%)ES=F E-Mini S&P 500 Dec 25 6,678.75 +83.50 (+1.27%)ETH-USD Ethereum USD 4,168.26 +423.76 (+11.32%)YM=F Mini Dow Jones Indus.-$5 Dec 25 46,110.00 +404.00 (+0.88%)Top economic events