Stock IdeasDec. 07, 2025 6:56 PM ETENTG, MSFT, LLY, WBD, COHR, DAL, PM, KMI, NTRA, TEVA, CPNG, MELI, QSR, WWD, C, SE, U, DAKT, YPF, TSM, MSFT:CA, LLY:CA, QSR:CA, TEVJF, TSMWF, CITI:CA, ZLLY:CA, ZMSF:CA, ZYNS:CA, CRESY, IRS, GGAL, EDN, INSM, PCT, AMZN, ROKU, FIGR, STUB, WAB, META, NAMS, CRS, TWLO, VRNAJohn Vincent25.89K FollowersCommentsSummaryDuquesne Family Office's ~$4.06B 13F portfolio remains concentrated, with the top five holdings—Natera, Insmed, Teva Pharma, Taiwan Semi, and Woodward—comprising ~39%.Significant new positions include Amazon, Figure Technology, Stubhub, and Meta Platforms; notable disposals were Microsoft, Eli Lilly, Warner Bros Discovery, and Philip Morris.Stake increases in Natera, Insmed, Teva, Coupang, Mercadolibre, and DocuSign, reflecting conviction in these growth-oriented names.Several positions, including Woodward, Roku, Citigroup, and EQT, saw reductions, signaling active portfolio rotation and risk management.cagkansayin/iStock via Getty ImagesThis article is part of a series that provides an ongoing analysis of the changes made to Duquesne Family Office’s 13F stock portfolio on a quarterly basis. It is based on Stanley Druckenmiller’s regulatory 13FThis article was written byJohn Vincent25.89K FollowersFocused on analyzing 13F reports & building tools to help DIY investors generate absolute returns through exploiting inefficiency, volatility, and momentum. Asymmetric Bets Focus. Broader commentary for DIY investors at Substack: https://diyabsolutereturns.substack.com/ . Check out my new book Demystifying Bitcoin - Paving the Way to Global Digital Money: https://t.co/edXb1HbihuAnalyst’s Disclosure:I/we have a beneficial long position in the shares of AMZN, META, WBD either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.CommentsQuick InsightsNTRA remains the largest position at 13.18% of the portfolio, with a minor ~4% stake increase, reflecting sustained high conviction despite the stock's significant appreciation.Both MSFT and LLY were fully exited this quarter after recent purchases, highlighting a willingness to quickly rotate out of large-cap winners and reallocate capital to new opportunities.New stakes in Amazon (AMZN), Figure Technology (FIGR), Stubhub (STUB), and Meta (META) suggest a renewed focus on technology, digital platforms, and innovation-driven growth.Recommended For You