Bora E, Eyuboglu MS, Cesim E, Demir M, Yalincetin B, Ermis C, et al. Social cognition and neurocognition in first-episode bipolar disorder and psychosis: the effect of negative and attenuated positive symptoms. J Affect Disord. 2024;351:356–63.PubMed Google Scholar Haller CS, Padmanabhan JL, Lizano P, Torous J, Keshavan M. Recent advances in understanding schizophrenia. F1000Prime Rep. 2014;6:57.PubMed PubMed Central Google Scholar Gama Marques J, Ouakinin S. Schizophrenia-schizoaffective-bipolar spectra: an epistemological perspective. CNS Spectr. 2021;26:197–201.PubMed Google Scholar Guloksuz S, van Os J. The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum. Psychol Med. 2018;48:229–44.PubMed Google Scholar Türközer HB, Lizano P, Adhan I, Ivleva EI, Lutz O, Zeng V, et al. Regional and sex-specific alterations in the visual cortex of individuals with psychosis spectrum disorders. Biol Psychiatry. 2022;92:396–406.PubMed Google Scholar Boudriot E, Gabriel V, Popovic D, Pingen P, Yakimov V, Papiol S, et al. Signature of altered retinal microstructures and electrophysiology in schizophrenia spectrum disorders is associated with disease severity and polygenic risk. Biol Psychiatry. 2024;96:792–803.PubMed Google Scholar Demirlek C, Verim B, Zorlu N, Demir M, Yalincetin B, Eyuboglu MS, et al. Functional brain networks in clinical high-risk for bipolar disorder and psychosis. Psychiatry Res. 2024;342:116251.PubMed Google Scholar Raymond N, Reinhart RMG, Keshavan M, Lizano P. An integrated neuroimaging approach to inform transcranial electrical stimulation targeting in visual hallucinations. Harv Rev Psychiatry. 2022;30:181–90.PubMed PubMed Central Google Scholar Silverstein SM, Choi JJ, Green KM, Bowles-Johnson KE, Ramchandran RS. Schizophrenia in translation: why the eye? Schizophr Bull. 2022;48:728–37.PubMed PubMed Central Google Scholar Kiely C, Douglas KAA, Douglas VP, Miller JB, Lizano P. Overlap between ophthalmology and psychiatry - A narrative review focused on congenital and inherited conditions. Psychiatry Res. 2024;331:115629.PubMed Google Scholar Zhao B, Li Y, Fan Z, Wu Z, Shu J, Yang X, et al. Eye-brain connections revealed by multimodal retinal and brain imaging genetics. Nat Commun. 2024;15:6064.PubMed PubMed Central Google Scholar Silverstein SM, Demmin DL, Schallek JB, Fradkin SI. Measures of retinal structure and function as biomarkers in neurology and psychiatry. Biomarkers in Neuropsychiatry. 2020;2:100018.Google Scholar Green KM, Choi JJ, Ramchandran RS, Silverstein SM. OCT and OCT angiography offer new insights and opportunities in schizophrenia research and treatment. Front Digit Health. 2022;4:836851.PubMed PubMed Central Google Scholar Bannai D, Lizano P, Kasetty M, Lutz O, Zeng V, Sarvode S, et al. Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: a preliminary study. Psychiatry Res Neuroimaging. 2020;299:111061.PubMed PubMed Central Google Scholar Moran C, Xu ZY, Mehta H, Gillies M, Karayiannis C, Beare R, et al. Neuroimaging and cognitive correlates of retinal optical coherence tomography (OCT) measures at late middle age in a twin sample. Sci Rep. 2022;12:9562.PubMed PubMed Central Google Scholar Kallen NM, Cecere G, Palpella D, Rabe F, Georgiadis F, Badstübner P et al. The retina across the psychiatric spectrum: a systematic review and meta-analysis. medRxiv [Preprint]. 2024. https://doi.org/10.1101/2024.11.07.24316925.Almonte MT, Capellán P, Yap TE, Cordeiro MF. Retinal correlates of psychiatric disorders. Ther Adv Chronic Dis. 2020;11:2040622320905215.PubMed PubMed Central Google Scholar Sheehan N, Bannai D, Silverstein SM, Lizano P. Neuroretinal alterations in schizophrenia and bipolar disorder: an updated meta-analysis. Schizophr Bull. 2024;50:1067–82.PubMed PubMed Central Google Scholar Prasannakumar A, Kumar V, Mailankody P, Appaji A, Battu R, Berendschot T, et al. A systematic review and meta-analysis of optical coherence tomography studies in schizophrenia, bipolar disorder and major depressive disorder. World J Biol Psychiatry. 2023;24:707–20.PubMed Google Scholar Andreazza AC, Barros LF, Behnke A, Ben-Shachar D, Berretta S, Chouinard VA, et al. Brain and body energy metabolism and potential for treatment of psychiatric disorders. Nat Ment Health. 2025;3:763–71.Google Scholar Licinio J, Wong ML. Advances in molecular psychiatry – March 2023: mitochondrial function, stress, neuroinflammation – bipolar disorder, psychosis, and Alzheimer’s disease. Mol Psychiatry. 2023;28:968–71.PubMed PubMed Central Google Scholar Komatsu H, Onoguchi G, Jerotic S, Kanahara N, Kakuto Y, Ono T, et al. Retinal layers and associated clinical factors in schizophrenia spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry. 2022;27:3592–616.PubMed Google Scholar Lee SS, Lingham G, Alonso-Caneiro D, Charng J, Chen FK, Yazar S, et al. Macular thickness profile and its association with best-corrected visual acuity in healthy young adults. Transl Vis Sci Technol. 2021;10:8.PubMed PubMed Central Google Scholar Khawaja AP, Chua S, Hysi PG, Georgoulas S, Currant H, Fitzgerald TW, et al. Comparison of associations with different macular inner retinal thickness parameters in a large cohort: the UK biobank. Ophthalmology. 2020;127:62–71.PubMed Google Scholar Chua SYL, Dhillon B, Aslam T, Balaskas K, Yang Q, Keane PA, et al. Associations with photoreceptor thickness measures in the UK biobank. Sci Rep. 2019;9:19440.PubMed PubMed Central Google Scholar Banghart M, Lee K, Bahrainian M, Staggers K, Amos C, Liu Y, et al. Total retinal thickness: a neglected factor in the evaluation of inner retinal thickness. BMJ Open Ophthalmol. 2022;7:e001061.PubMed PubMed Central Google Scholar Silverstein SM, Paterno D, Cherneski L, Green S. Optical coherence tomography indices of structural retinal pathology in schizophrenia. Psychol Med. 2018;48:2023–33.PubMed Google Scholar Velez-Perez E, Raymond N, Kiely C, Molho W, Trotti R, Harris C, et al. Electroretinographic dysfunction, insulin resistance, and childhood trauma in early-course psychosis: a case-control exploratory study. Biomarkers in Neuropsychiatry. 2024;10:100088.PubMed PubMed Central Google Scholar Wagner SK, Cortina-Borja M, Silverstein SM, Zhou Y, Romero-Bascones D, Struyven RR, et al. Association between retinal features from multimodal imaging and schizophrenia. JAMA Psychiatry. 2023;80:478–87.PubMed PubMed Central Google Scholar Yusifova A, Atagün MI, Uğurlu N, Malekghasemi S, Şenat A, Demirlek C, et al. Retinal fundus imaging in bipolar disorder: a pilot study. Psychiatry Clin Neurosci. 2020;74:85–6.PubMed Google Scholar Blose BA, Lai A, Crosta C, Thompson JL, Silverstein SM. Retinal Neurodegeneration as a Potential Biomarker of Accelerated Aging in Schizophrenia Spectrum Disorders. Schizophr Bull. 2023;49:1316–24.PubMed PubMed Central Google Scholar Silverstein SM, Fradkin SI, Demmin DL. Schizophrenia and the retina: towards a 2020 perspective. Schizophr Res. 2020;219:84–94.PubMed Google Scholar Blose BA, Silverstein SM, Stuart KV, Keane PA, Khawaja AP, Wagner SK. Association between polygenic risk for schizophrenia and retinal morphology: a cross-sectional analysis of the United Kingdom Biobank. Psychiatry Res. 2024;339:116106.PubMed Google Scholar Boudriot E, Stephan M, Rabe F, Smigielski L, Schmitt A, Falkai P, et al. Genetic analysis of retinal cell types in neuropsychiatric disorders. JAMA Psychiatry. 2025;82:285–95.PubMed Google Scholar Hébert M, Gagné AM, Paradis ME, Jomphe V, Roy MA, Mérette C, et al. Retinal response to light in young non-affected offspring at high genetic risk of neuropsychiatric brain disorders. Biol Psychiatry. 2010;67:270–4.PubMed Google Scholar Gagné AM, Moreau I, St-Amour I, Marquet P, Maziade M. Retinal function anomalies in young offspring at genetic risk of schizophrenia and mood disorder: meaning for illness pathophysiology. Schizophr Res. 2020;219:19–24.PubMed Google Scholar Maziade M, Bureau A, Jomphe V, Gagné AM. Retinal function and preclinical risk traits in children and adolescents at genetic risk of schizophrenia and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2022;112:110432.PubMed Google Scholar Bora E, Eyuboglu MS, Cesim E, Demir M, Yalincetin B, Ermis C, et al. Neurocognition and social cognition in youth and young adults at ultra-high-risk for psychosis and bipolar disorder. Schizophr Res. 2024;266:58–65.PubMed Google Scholar McCutcheon RA, Keefe RSE, McGuire PK. Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment. Mol Psychiatry. 2023;28:1902–18.PubMed PubMed Central Google Scholar Demirlek C, Arslan B, Eyuboglu MS, Yalincetin B, Atas F, Cesim E, et al. Retina in clinical high-risk and first-episode psychosis. Schizophr Bull. 2024;sbae189. https://doi.org/10.1093/schbul/sbae189.Molho W, Stiltner B, Raymond N, Kiely C, Trotti R, Harris C, et al. Retinal electrophysiological alterations are associated with cognition in early course psychosis. Schizophr Res. 2024;274:137–41.PubMed PubMed Central Google Scholar Chua SYL, Lascaratos G, Atan D, Zhang B, Reisman C, Khaw PT, et al. Relationships between retinal layer thickness and brain volumes in the UK Biobank cohort. Eur J Neurol. 2021;28:1490–8.PubMed Google Scholar Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12:e1001779.PubMed PubMed Central Google Scholar von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344–9.Google Scholar Nicholls SG, Quach P, von Elm E, Guttmann A, Moher D, Petersen I, et al. The REporting of studies conducted using observational routinely-collected health data (RECORD) statement: methods for arriving at consensus and developing reporting guidelines. PLoS ONE. 2015;10:e0125620.PubMed PubMed Central Google Scholar Yang Q, Reisman CA, Wang Z, Fukuma Y, Hangai M, Yoshimura N, et al. Automated layer segmentation of macular OCT images using dual-scale gradient information. Opt Express. 2010;18:21293–307.PubMed Google Scholar Ko F, Foster PJ, Strouthidis NG, Shweikh Y, Yang Q, Reisman CA, et al. Associations with retinal pigment epithelium thickness measures in a large cohort: results from the UK biobank. Ophthalmology. 2017;124:105–17.PubMed Google Scholar Townsend P, Phillimore P, Beattie A Health and deprivation: inequality and the North. Routledge 2023.Lyall DM, Cullen B, Allerhand M, Smith DJ, Mackay D, Evans J, et al. Cognitive test scores in UK biobank: data reduction in 480,416 participants and longitudinal stability in 20,346 participants. PLoS ONE. 2016;11:e0154222.PubMed PubMed Central Google Scholar Fawns-Ritchie C, Deary IJ. Reliability and validity of the UK Biobank cognitive tests. PLoS ONE. 2020;15:e0231627.PubMed PubMed Central Google Scholar Li CY, Garg I, Bannai D, Kasetty M, Katz R, Adhan I, et al. Sex-specific changes in choroid vasculature among patients with schizophrenia and bipolar disorder. Clin Ophthalmol. 2022;16:2363–71.PubMed PubMed Central Google Scholar Gao X, Starmer J, Martin ER. A multiple-testing correction method for genetic association studies using correlated single-nucleotide polymorphisms. Genet Epidemiol. 2008;32:361–9. https://doi.org/10.1002/gepi.20310Article PubMed Google Scholar Komatsu H, Onoguchi G, Silverstein SM, Jerotic S, Sakuma A, Kanahara N, et al. Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography. Mol Psychiatry. 2023.Ayık B, Kaya H, Tasdelen R, Sevimli N. Retinal changes in bipolar disorder as an endophenotype candidate: comparison of OCT-detected retinal changes in patients, siblings, and healthy controls. Psychiatry Res. 2022;313:114606.PubMed Google Scholar Kaya H, Ayık B, Tasdelen R, Sevimli N, Ertekin E. Comparing retinal changes measured by optical coherence tomography in patients with schizophrenia and their siblings with healthy controls: Are retinal findings potential endophenotype candidates? Asian J Psychiatr. 2022;72:103089.PubMed Google Scholar Kurtulmus A, Elbay A, Parlakkaya FB, Kilicarslan T, Ozdemir MH, Kirpinar I. An investigation of retinal layer thicknesses in unaffected first-degree relatives of schizophrenia patients. Schizophr Res. 2020;218:255–61.PubMed Google Scholar Rabe F, Smigielski L, Georgiadis F, Kallen N, Omlor W, Edkins V, et al. Genetic susceptibility to schizophrenia through neuroinflammatory pathways associated with retinal thinness. Nat Ment Health. 2025;3:538–47. https://doi.org/10.1038/s44220-025-00414-6Article PubMed PubMed Central Google Scholar Samani NN, Proudlock FA, Siram V, Suraweera C, Hutchinson C, Nelson CP, et al. Retinal layer abnormalities as biomarkers of schizophrenia. Schizophr Bull. 2018;44:876–85.PubMed Google Scholar Whitmore SS, DeLuca AP, Andorf JL, Cheng JL, Mansoor M, Fortenbach CR, et al. Modeling rod and cone photoreceptor cell survival in vivo using optical coherence tomography. Sci Rep. 2023;13:6896.PubMed PubMed Central Google Scholar Xu Y, Aung HL, Hesam-Shariati N, Keay L, Sun X, Phu J, et al. Contrast sensitivity, visual field, color vision, motion perception, and cognitive impairment: a systematic review. J Am Med Dir Assoc. 2024;25:105098.PubMed Google Scholar Ward DD, Mauschitz MM, Bönniger MM, Merten N, Finger RP, Breteler MMB. Association of retinal layer measurements and adult cognitive function: a population-based study. Neurology. 2020;95:e1144–e1152.PubMed Google Scholar Mutlu U, Bonnemaijer PWM, Ikram MA, Colijn JM, Cremers LGM, Buitendijk GHS, et al. Retinal neurodegeneration and brain MRI markers: the rotterdam study. Neurobiol Aging. 2017;60:183–91.PubMed Google Scholar Vandewalle G, Maquet P, Dijk DJ. Light as a modulator of cognitive brain function. Trends Cogn Sci. 2009;13:429–38.PubMed Google Scholar Thivierge J-P, Marcus GF. The topographic brain: from neural connectivity to cognition. Trends Neurosci. 2007;30:251–9.PubMed Google Scholar Diamond A, Silverstein SM, Keane BP. Visual system assessment for predicting a transition to psychosis. Transl Psychiatry. 2022;12:351.PubMed PubMed Central Google Scholar Schoeler T, Speed D, Porcu E, Pirastu N, Pingault JB, Kutalik Z. Participation bias in the UK Biobank distorts genetic associations and downstream analyses. Nat Hum Behav. 2023;7:1216–27.PubMed PubMed Central Google Scholar Lizano P, Velez-Perez E. Multimodal retinal imaging findings in schizophrenia spectrum disorders. Biol Psychiatry. 2024;96:769–71.PubMed Google Scholar Demirlek C, Atas F, Yalincetin B, Gurbuz MS, Cesim E, Demir M, et al. Choroidal structural analysis in ultra-high risk and first-episode psychosis. Eur Neuropsychopharmacol. 2023;70:72–80.PubMed Google Scholar Altun IK, Turedi N, Aras N, Atagun MI. Psychopharmacological signatures in the retina in schizophrenia and bipolar disorder: an optic coherence tomography study. Psychiatr Danub. 2020;32:351–8.PubMed Google Scholar Legge SE, Pardiñas AF, Woolway G, Rees E, Cardno AG, Escott-Price V, et al. Genetic and phenotypic features of schizophrenia in the UK Biobank. JAMA Psychiatry. 2024;81:681–90. https://doi.org/10.1001/jamapsychiatry.2024.0200Article PubMed PubMed Central Google Scholar