Pictures of DNA often look very tidy—the strands of the double helix neatly wind around each other, making it seem like studying genetics should be relatively straightforward. In truth, these strands aren't often so perfectly picturesque. They are constantly twisting, bending, and even being repaired by minuscule proteins. These are movements on the nanoscale, and capturing them for study is extremely challenging. Not only do they wriggle about, but the camera's fidelity must be high enough to focus on the tiniest details.