New drug could help slow progression of motor neurone disease | The IndependentNotifications can be managed in browser preferences.Jump to contentIndependentSwipe for next articleIndependent Bulletin homepageDownload ourSocial PartnerWe are 8 logo (opens in a new tab)AllNewsSportCultureLifestyleStorm NewtonTuesday 11 November 2025 01:51 GMTThe Signs And Symptoms Of Motor Neurone DiseaseA new medicine, M102, has been discovered by scientists at the University of Sheffield’s Institute for Translational Neuroscience (SITraN) in collaboration with U.S. biotech company Aclipse Therapeutics.M102 protects nerve cells damaged by motor neurone disease (MND), offering hope of substantially slowing the progression of the condition, for which there is currently no cure.Preclinical studies demonstrated that M102 improved movement and nerve function in mice and protected motor neurones grown in a lab from damage caused by MND cells.The medicine works by activating two protective systems within cells, NRF2 and HSF1, which help nerves combat stress, reduce inflammation and clear away damaged proteins.Researchers are now optimistic that human trials for M102 can proceed, aiming to provide a significant treatment for MND patients.In fullMajor motor neurone disease breakthrough offers hope to those with ‘cruel’ conditionThank you for registeringPlease refresh the page or navigate to another page on the site to be automatically logged inPlease refresh your browser to be logged in