What is Lyme Disease? See its causes, stages, symptoms, areas where it is common in the US, diagnosis, treatment, prevention and long-term effects. Justin Timberlake has shared that he was diagnosed with Lyme disease during his two-year tour. The illness, caused by infected tick bites, can lead to fatigue, nerve pain, and long-term health issues. Timberlake opened up to raise awareness and support others battling this condition.