News & ViewsPublished: 30 July 2025ImplantsSergei Butenko1 &Maksim V. Plikus ORCID: orcid.org/0000-0002-8845-25592,3,4 Nature Biomedical Engineering (2025)Cite this articleSubjectsImplantsRegenerative medicineOsteopontin is necessary and sufficient to reduce fibrosis around silicone implants coated with an acellular dermal matrix.ReferencesWan, D. & Rohrich, R. J. Plast. Reconstr. Surg. 137, 826–841 (2016).CAS PubMed Google Scholar Atlan, M., Nuti, G., Wang, H., Decker, S. & Perry, T. J. Mech. Behav. Biomed. Mater. 88, 377–385 (2018).PubMed Google Scholar Noskovicova, N. et al. Nat. Biomed. Eng. 5, 1437–1456 (2021).CAS PubMed Google Scholar Chun, Y. S. et al. Plast. Reconstr. Surg. 125, 429–436 (2010).CAS PubMed Google Scholar Griffin, M. F. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-025-01361-4 (2025).Article PubMed Google Scholar Salzberg, C. A., Ashikari, A. Y., Berry, C. & Hunsicker, L. M. Plast. Reconstr. Surg. 138, 329–337 (2016).CAS PubMed Google Scholar Li, L. et al. Front. Immunol. 14, 1176639 (2023).CAS PubMed PubMed Central Google Scholar Reggio, A. et al. FASEB J. 39, e70448 (2025).CAS PubMed Google Scholar Jin, S. et al. Nat. Commun. 12, 1088 (2021).CAS PubMed PubMed Central Google Scholar Tsai, A. T. et al. Biomaterials 26, 5835–5843 (2005).CAS PubMed Google Scholar Makishi, S., Yamazaki, T. & Ohshima, H. Int. J. Mol. Sci. 23, 1039 (2022).CAS PubMed PubMed Central Google Scholar Chen, Q. et al. Stem Cells 32, 327–337 (2014).CAS PubMed Google Scholar Wang, X. et al. Nature 618, 808–817 (2023).CAS PubMed PubMed Central Google Scholar Kurzbach, D. et al. Biochemistry 52, 5167–5175 (2013).CAS PubMed Google Scholar Malmström, J. et al. J. Biomed. Mater. Res. A 95A, 518–530 (2010).Google Scholar Download referencesAuthor informationAuthors and AffiliationsAllergan Aesthetics, an AbbVie company, Irvine, CA, USASergei ButenkoDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USAMaksim V. PlikusSue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USAMaksim V. PlikusCenter for Complex Biological Systems, University of California, Irvine, Irvine, CA, USAMaksim V. PlikusAuthorsSergei ButenkoView author publicationsSearch author on:PubMed Google ScholarMaksim V. PlikusView author publicationsSearch author on:PubMed Google ScholarCorresponding authorCorrespondence to Maksim V. Plikus.Ethics declarationsCompeting interestsS.B. is an employee of Allergan Aesthetics, an AbbVie Company. M.V.P. declares no competing interests.Rights and permissionsReprints and permissionsAbout this article