The brand new EFL season kicks off on Friday night as Luton and Wimbledon go head to head at Kenilworth Road in the opening League One clash of the campaign.Luton v Wimbledon best betsNahki Wells to score first – 17/5 with LadbrokesLuton to win to nil – 6/4 with LadbrokesLADBROKES – Bet £5 and get £20 in free bets – CLAIM HERE*Luton v Wimbledon oddsFind the latest match odds for Luton v Wimbledon on Ladbrokes. Odds are subject to change.Luton – 1/2Draw – 10/3Wimbledon – 17/4Luton v Wimbledon predictionFriday night will see Luton kick off their League One campaign against Wimbledon, their first time in the third tier since achieving promotion into the Championship in 2019.Last season the Hatters became the first side to fall to back to back relegations out of the Premier League since Sunderland seven years ago.Matt Bloomfield’s side will be looking to earn an instant promotion back into the second tier, and are currently priced as the favourites to win the third division title, with of their squad containing members who turned out for them in the Premier League two seasons ago.Luton won five out of their six pre-season friendlies in preparation for the new campaign, beating Boreham Wood, Slovenian side Triglav Kranj, Colchester, Gillingham and Southend, before signing off at home last Saturday with a goalless draw against Europa League champions Tottenham.The Bedfordshire side’s first match of the season sees them take on a newly promoted Wimbledon side who will be taking part in their first League One match since their relegation in 2022, and head into the new campaign as favourites for relegation back into League Two.Last season’s League Two play-off champions after a 1-0 win over Walsall, have been dealt what on paper is the toughest possible start to their League One campaign with a trip to Kenilworth Road to kick off proceedings.Johnnie Jackson’s side have endured a tricky run of pre-season results, winning only one of their six matches, which came against Enfield Town – with defeats in their last three outings, against Championship side Millwall and National League duo Sutton and Southend.Title favourites Luton will be expected to make relatively light work of the visit of relegation Wimbledon in Friday night’s EFL curtain raiser, with a 3-0 home win seeming a reasonable prediction.Luton v Wimbledon predicted line upsLuton (4-3-3): Keeley; Walters, Makosso, Andersen, Naismith; Alli, Lonwijk, Clark; Baptiste, Wells, SavilleWimbledon (3-5-2): Bishop; Harbottle, Ogundere, Johnson; Hippolyte, Smith, Reeves, Hutchinson, Seddon; Stevens, BrowneLuton v Wimbledon betting tipsNahki Wells to score first – 17/5 with LadbrokesLuton to win to nil – 6/4 with LadbrokesLuton v Wimbledon bet builderLuton to win to nil, Nahki Wells to score first, over 2.5 goals – 31/2 with LadbrokesThe title favourites host the relegation favourites in League One on Friday night to kick off the 2025-26 EFL season, with Luton determined to kickstart the season with a convincing victory in front of their home fans after suffering back to back relegations in the last two seasons.New striker Nahki Wells hit double figures for goals in the Championship last season but wasn’t offered a new contract of Bristol City, much to the delight of Luton who picked him up on a free, and the Bermudian will be eager to make a strong start for his new team in front of his new home fans.How to watch Luton v WimbledonLocation: Kenilworth Road, LutonDate and time: Friday 1st August 2025, 8pmHow to watch: Sky Sports Main Event, Sky Sports Football, Sky Sports Ultra HDRLADBROKES – Bet £5 and get £20 in free bets – CLAIM HERE*Claim £1000+ worth of free bets and betting offers from our bookmaker partners – CLAIM HERECommercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. GambleAware.orgRemember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamcare – www.gamcare.org.ukGambleAware – www.gambleaware.orgFind our detailed guide on responsible gambling practices here.For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.*18+. New UK & ROI customers. Min first deposit £5 and place win or each-way bet within 14 days of account registration at min odds 1/2 to get 4 x £5 free bets. Restrictions & T&Cs apply.