Ultragenyx Pharmaceutical Inc. (RARE) Gets FDA CRL for UX111, Vows Quick Resubmission

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Ultragenyx Pharmaceutical Inc. stands first on our list.Ultragenyx Pharmaceutical Inc. (NASDAQ:RARE), based in Novato, California, focuses on developing therapies for rare and ultra-rare genetic diseases and tops our list for being one of the best growth stocks. The company’s portfolio includes commercial products and a strong late-stage pipeline targeting high-need conditions such as Sanfilippo syndrome type A, osteogenesis imperfecta, Angelman syndrome, and glycogen storage diseases.A key recent development was the FDA’s Complete Response Letter (CRL) on July 11, 2025, for the company’s Biologics License Application for UX111, a gene therapy for Sanfilippo syndrome type A. While the FDA highlighted chemistry, manufacturing, and controls (CMC) issues, it also recognized the robust clinical and biomarker data, affirming the therapy’s efficacy. The business intends to resolve the CMC concerns and resubmit the application, expecting a six-month review.Beyond UX111, Ultragenyx Pharmaceutical Inc. (NASDAQ:RARE) is advancing other promising therapies. UX143, targeting osteogenesis imperfecta, is progressing toward final analysis after a Phase 3 study. GTX-102, for Angelman syndrome, recently received the FDA Breakthrough Therapy designation, indicating its potential for accelerated development.The corporation’s strategy is notable for its modality-agnostic approach, leveraging gene therapies, monoclonal antibodies, and antisense oligonucleotides. This diversified platform reduces regulatory risk while maximizing impact across several rare disorders.Ultragenyx Pharmaceutical Inc. (RARE) Gets FDA CRL for UX111, Vows Quick ResubmissionA doctor examining a patient using a vascular disease diagnosis device.Adding to its momentum, Ultragenyx Pharmaceutical Inc. (NASDAQ:RARE) recently gained Health Canada approval to expand the use of Evkeeza to infants as young as six months with homozygous familial hypercholesterolemia (HoFH), enhancing its commercial reach.While we acknowledge the potential of GOOGL as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.READ NEXT: The Best and Worst Dow Stocks for the Next 12 Months and 10 Unstoppable Stocks That Could Double Your Money.Disclosure: None.Terms and Privacy PolicyPrivacy & Cookie SettingsMore InfoS&P 5006,389.65 +26.75 (+0.42%)Dow 3044,418.79 -42.49 (-0.10%)Nasdaq21,306.51 +176.84 (+0.84%)Russell 20002,217.48 -14.91 (-0.67%)VIX16.09 +0.61 (+3.96%)Gold3,348.80 -4.00 (-0.12%)PortfolioSign in to access your portfolioSign inTop gainersAPLD Applied Digital Corporation 13.58 +3.55 (+35.39%)PI Impinj, Inc. 160.00 +37.79 (+30.92%)APLS Apellis Pharmaceuticals, Inc. 22.15 +3.15 (+16.58%)AMSC American Superconductor Corporation 55.14 +11.19 (+25.48%)CVNA Carvana Co. 393.75 +60.16 (+18.03%)Top losersALGN Align Technology, Inc. 181.88 +0.95 (+0.53%)CFLT Confluent, Inc. 17.94 -8.47 (-32.06%)PARAA Paramount Global 18.13 -5.16 (-22.16%)SPSC SPS Commerce, Inc. 113.82 -25.74 (-18.44%)BAX Baxter International Inc. 22.91 -5.14 (-18.32%)Most activeNVDA NVIDIA Corporation 179.94 +0.67 (+0.37%)APLD Applied Digital Corporation 13.58 +3.55 (+35.39%)SOFI SoFi Technologies, Inc. 22.89 +1.01 (+4.64%)GRAB Grab Holdings Limited 5.01 -0.28 (-5.39%)NIO NIO Inc. 4.8150 +0.3050 (+6.76%)Earnings eventsTrending tickersMSFT Microsoft Corporation 536.76 +23.52 (+4.58%)META Meta Platforms, Inc. 780.40 +85.18 (+12.25%)FIG Figma, Inc. 33.00 0.00 (0.00%)APLD Applied Digital Corporation 13.42 +3.39 (+33.76%)RBLX Roblox Corporation 140.82 +15.88 (+12.71%)Top economic events