Country: World Source: World Health Organization Please refer to the attached file. The currently available vaccines for priority diseases offer substantial health benefits. The relative value of these vaccines depends on the burden of disease, the cost of the vaccine, and the available resources for the introduction of the vaccine into the national immunization program (NIP). Since population characteristics, the burden of disease, and available resources vary between subregions and countries, the decision to introduce new and relatively expensive vaccines requires a set of evidence that reflects a country’s conditions. This also applies to policy changes affecting vaccines already included in national immunization schedules. A national immunization technical advisory group (NITAG) is a technical resource that provides evidence-based advice to national authorities on immunization. A multidisciplinary and informed group with a variety of expertise will give impartial recommendations on vaccines and vaccine-related issues aimed at improving population health. This technical resource is particularly important in view of the vast and complex body of knowledge on immunization and will help counter the pressure from external interest groups. This operational guide provides key considerations for the setup of a national immunization technical advisory group (NITAG), information on their internationally established quality standards and guidance for optimal functioning, and recommendations for development and integration into the national policy process. This document is the result of numerous countries' requests to develop guidance on the minimum requirements of NITAGs and quality standards in an accessible language (also available in Spanish and French), which can also be used as an advocacy tool for establishing or strengthening NITAGs and increasing key immunization stakeholders' and partners' support.