Tottenham Hotspur travel across London this weekend to face West Ham United, and with a busy schedule ahead, Thomas Frank could be set to hand first starts of the season to several players who have been waiting for their chance to impress.Tottenham Hotspur will be desperate to bounce back to winning ways when they face off against London rivals West Ham United at the London Stadium.Several Tottenham players have just returned from international duty, where they picked up much-needed minutes to sharpen their fitness, and Frank will be mindful of how he rotates his squad with a heavy run of fixtures looming.The UEFA Champions League league phase begins the week after the West Ham clash, which means Frank may turn to some of his fresh options to spread the load across the squad. Six players, in particular, could be in line for their first starts of the season, and we have highlighted each one of them.Credit: @thefrederikkejensen / InstagramXavi Simons could make first Tottenham start vs West HamXavi Simons, who only arrived at Tottenham days before the summer window slammed shut, looks primed for his first full start this weekend.Tottenham have lacked a creative spark in midfield, a problem that was glaringly obvious in the defeat against Bournemouth, and with Simons fit after minutes on international duty, the Dutch international seems ready to step in.Spotted in training on Wednesday, Simons was heavily involved in tactical drills, which highlights Frank’s plans for him. At £51 million, Tottenham’s new signing is unlikely to be eased in slowly, and with the Champions League starting next week, he may be thrown straight into the starting XI at the London Stadium.Randal Kolo Muani pushing for first Tottenham startRandal Kolo Muani is another big signing who could be handed a chance, as Tottenham look to rediscover their winning rhythm.The French striker stayed back during the international break, giving him valuable time on the training ground with Frank and his staff, which may prove useful as he adapts to life in North London.Richarlison, meanwhile, was in action for Brazil until midweek and played just over an hour, so Frank could decide to keep him fresh for the Champions League, meaning Muani might get his opportunity to lead the line, although a substitute role still looks the likelier outcome depending on the flow of the game.Dominic Solanke return depends on injuryDominic Solanke has barely been involved for Tottenham this season, with injuries keeping him sidelined in the early weeks.The striker missed the clash with Bournemouth due to a hamstring issue, although there is optimism that he might return after the international break.If Solanke is passed fit, then he could be in contention to face West Ham, but given Tottenham’s attacking options and the recent arrival of Kolo Muani, it feels unlikely Frank risks starting him immediately.(Credit @thefrederikkejensen / Instagram)Mathys Tel looking for Tottenham chanceMathys Tel has been in the headlines after being excluded from Tottenham’s Champions League squad list.The French forward responded in style during the break with a thunderous strike for France Under-21s, which reminded everyone of his talent and potential.Tottenham fans have been calling for Tel to be given a chance under Frank, and with him ineligible for midweek Champions League action, the 20-year-old might just get a run out against West Ham.Wilson Odobert waiting for Tottenham startWilson Odobert is yet to start a game under Thomas Frank, with the manager preferring Mohammed Kudus and Brennan Johnson as his wide options.The competition for places is fierce, and it is difficult to see where Odobert fits in at present, although he does provide flexibility by being able to play centrally or on either flank.That said, Simons is expected to play in the number ten role, and both Kudus and Johnson remain in strong form, so while Odobert could get a look in, it feels more likely that he will remain an impact option from the bench.Destiny Udogie ready for Tottenham breakthroughDestiny Udogie made his first competitive appearance of the season against Bournemouth, coming off the bench and offering plenty of attacking intent from full-back.The Italian did not feature for his national side during the break, so he will be fresh and ready if Frank chooses to make changes to his defensive set-up.Pedro Porro has not been convincing so far this season, having been beaten too easily on several occasions, so Udogie could be handed his chance from the off, with Djed Spence providing cover on the opposite flank if needed.READ MORE: Player says he ‘couldn’t be happy at Tottenham’ but they refused to terminate his contractThe post Six Tottenham players who could make first starts of the season vs West Ham appeared first on Spurs Web.