Manchester City fans have cause for concern after Omar Marmoush was substituted in pain while playing for Egypt.The forward was taken down while playing against Burkina Faso in World Cup Qualifying and instantly clutched his knee.A late lunge from a Burkina Faso midfielder sent Marmoush crashing to the groundFIFAFIFAMarmoush was instantly in pain on the deck clutching his knee[/caption]Receiving a ball from captain Mohamed Salah just inside his own half, Marmoush tried to jink into the middle of the pitch to find space and launch an attack.However, just as he got his foot on the ball for a second touch, in came Mohamed Zougrana to send him crashing to the ground.Salah went straight over to his Premier League rival who kept holding his knee writhing in pain.The tackle occurred in the fourth minute of the match, but it took until the ninth for Marmoush to finally leave the pitch, perhaps showing just how much pain he was in.City’s injury list growsShould Marmoush be set for a spell on the sidelines, City’s injury list would increase to ten players.John Stones, Phil Foden, Savinho, Josko Gvardiol and Abdukodir Khusanov are all dealing with ailments, but could return for the weekend’s clash against Manchester United.Longer term absentees are Mateo Kovacic, Rayan Cherki and Kalvin Phillips.Marmoush has quickly become one of City’s most crucial players, scoring eight goals and assisting twice since his £60million January move from Eintracht Frankfurt.Tough fixture list for Man CityIt’s not just the players that are vital, but the fixtures too, with Pep Guardiola’s team facing three tough fixtures when they return from the international break.First up is the home Manchester derby on September 14, followed by a Champions League tie at home to Serie A winners Napoli four days later, and then a trip to Arsenal on September 21.City's injury listRayan Cherki, Thigh Injury, potential return: 01/11/2025Mateo Kovacic, Calf/Shin/Heel Injury, potential return: 04/10/2025Josko Gvardiol, Other, potential return: 14/09/2025Savinho, Other, potential return: 14/09/2025Marcus Bettinelli, Knock, potential return: 14/09/2025Abdukodir Khusano, Knock, potential return: 14/09/2025Philip Foden, Ankle/Foot, potential return: 14/09/2025John Stones, Other, potential return: 14/09/2025Kalvin Phillips, Calf/Shin/Heel, No Return DateMarmoush has become key at City since his January arrival and Guardiola will be eagerly awaiting updates back in the UKGettyCity are in need of points, having lost their last two Premier League games against Tottenham and Brighton, raising doubts about their title chances just three games into the season.Elsewhere during the international break star striker Erling Haaland picked up an injury, but it’s not one that will keep him out of action.The Norway talisman required stitches after busting his lip open on a bus door while travelling with the team.talkSPORT’s take on Man City’s title chargeDespite a win and two defeats to start the season, talkSPORT’s Danny Murphy is still backing Guardiola’s side to challenge.“It’s been a strange start to the season,” he said. “Away at Wolves they were good, Tottenham did a job on them, but even the first half against Brighton I thought they were a bit unlucky.“A two-horse race [between Liverpool and Arsenal] looks likely, but I wouldn’t write City off, because they’ve got so many good players.”