Comedian and host Conan O'Brien's "Clueless Gamer" segment is back, and the newest episode is all about Borderlands 4 and raising money for a good cause.In this segment, O'Brien plays Borderlands 4 alongside the two people--Brian Long and Liz Day--who donated the most money in the CharityBuzz auction supporting the charity Next for Autism. O'Brien does what he does best in the episode, roasting the game and playing poorly. In particular, he makes fun of Claptrap for being so annoying and questions why such an absurd game needs any kind of story at all.Next for Autism is a nonprofit that designs and launched programs to support people with autism. Long and Day donated the most money, winning the auction and a chance to play a game with O'Brien.Clueless Gamer was a regular series that generated many millions of views across numerous installments, but went dark for a while. The latest episode prior to the Borderlands 4 installment came in 2024 with Death Stranding's director's cut.One Clueless Gamer episode had Seth Rogen and Zach Efron draw a penis on O'Brien's face while playing Mario Kart 8. The show was so successful that TBS was considering a Clueless Gamer spin-off show, but that never happened.Borderlands 4 launches on September 12, but it actually unlocks starting at 9 PM PT on September 11. For more, be sure to check out GameSpot's Borderlands 4 preorder guide. The game launches this week for PS5, Xbox Series X|S, and PC, and comes to Switch 2 in October.Click the button below to add GameSpot as a preferred source on Google