The major US stock indices are closing lower with the broader indices down over 1.3% and the Dow 30, down -0.95%. Looking at the closing levels:Dow industrial average -453.19 points or -0.95% at 47501.55S&P index -90.69 points or -1.33% at 6740.02.NASDAQ index -361.31 points or -1.59% at 22387.68.Russell 2000 of small-cap stocks -60.27 points or - 2.33% at 2525.30.For the trading week: Dow industrial average fell -3.01%. S&P index fell -2.02%.NASDAQ index fell -1.24%Russell 2000 index fell -4.06%Here's a summary of the some of the week's biggest losers:The Carnage at a GlanceIt was a brutal week across the board, with 23 high capitalized stocks dropping 10% or more. The average decline among this group was roughly -13.5%, and the selling was broad-based across nearly every sector.Airlines took a direct hitWith the Iran war disrupting Middle East airspace and oil prices surging, airlines were among the hardest hit — Alaska Air (-18.02%), Southwest (-15.63%), American Airlines (-14.46%), United Airlines (-13.39%), and Delta (-10.18%) all made the list. The combination of spiking jet fuel costs and route disruptions is clearly hammering the sector.Consumer & Auto under pressureFord (-13.77%), Stellantis (-11.62%), and Whirlpool (-14.13%) suggest consumers and manufacturing are feeling the macro squeeze — likely a mix of tariff fears, rising input costs, and weakening demand signals.Tech & Semis sold off hardLam Research (-14.78%), ASML (-10.93%), Micron (-10.20%), Western Digital (-12.32%), and Arm (-10.22%) all saw double-digit losses — consistent with a risk-off rotation and concerns about global supply chain disruptions tied to the conflict.Defense paradoxRaytheon (-17.17%) is a notable outlier — typically a war-time beneficiary, but the stock may be caught in broader market de-risking or profit-taking after earlier gains.Mining took a hit tooNewmont (-10.55%) and Barrick (-10.48%) falling is somewhat surprising given gold's safe-haven status, possibly reflecting forced selling or broader equity outflows.Bottom line: This looks like a classic risk-off week driven by the Iran conflict, oil shock, and growing recession fears — with no sector truly spared. This article was written by Greg Michalowski at investinglive.com.